Sekhon, M., Cartwright, M., & Francis, J. J. (2017). Acceptability of healthcare interventions: An overview of reviews and development of a theoretical framework. BMC Health Services Research, 17, 88.
Article
PubMed
PubMed Central
Google Scholar
European Medicines Agency. (2013) Committee for medicinal products for human use, paediatric committee, guideline on pharmaceutical development of medicines for paediatric use. Available from: Http://www.Ema.Europa.Eu/docs/en_gb/document_library/scientific_guideline/2013/01/wc500137023.Pdf. Accessed 29 June 2018.
Venables, R., Batchelor, H., Hodson, J., Stirling, H., & Marriott, J. (2015). Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population. International Journal of Pharmaceutics, 480, 55–62.
Article
CAS
PubMed
Google Scholar
Koren, G., Rieder, M. J., & Amitai, Y. (2016). Averting the foul taste of pediatric medicines improves adherence and can be lifesaving – Pheburane™ (sodium phenylbutyrate). Patient Preference and Adherence, 10, 2141–2144.
Article
PubMed
PubMed Central
Google Scholar
Liu, F., Ranmal, S., Batchelor, H. K., Orlu-Gul, M., Ernest, T. B., Thomas, I. W., … Tuleu, C. (2014). Patient-centred pharmaceutical design to improve acceptability of medicines: Similarities and differences in paediatric and geriatric populations. Drugs, 74, 1871–1889.
Article
CAS
PubMed
PubMed Central
Google Scholar
European Medicines Agency. (2006) Committee for medicinal products for human use. Reflection paper: Formulations of choice for the paediatric population. Available from: Http://www.Ema.Europa.Eu/docs/en_gb/document_library/scientific_guideline/2009/09/wc500003782.Pdf. Accessed 29 June 2018.
Google Scholar
World Health Organization (2012). Who expert committee on specifications for pharmaceutical preparations. Development of paediatric medicines: Points to consider in formulation. In World Health Organization technical report series, (pp. 197–225).
Google Scholar
Cram, A., Breitkreutz, J., Desset-Brethes, S., Nunn, T., & Tuleu, C. (2009). Challenges of developing palatable oral paediatric formulations. International Journal of Pharmaceutics, 365, 1–3.
Article
CAS
PubMed
Google Scholar
Mistry, P., & Batchelor, H. (2017). Evidence of acceptability of oral paediatric medicines: A review. The Journal of Pharmacy and Pharmacology, 69, 361–376.
Article
CAS
PubMed
Google Scholar
Ruiz, F., Vallet, T., Pense-Lheritier, A. M., & Aoussat, A. (2017). Standardized method to assess medicines’ acceptability: Focus on paediatric population. The Journal of Pharmacy and Pharmacology, 69, 406–416.
Article
CAS
PubMed
Google Scholar
Vallet, T., Ruiz, F., Lavarde, M., Pense-Lheritier, A. M., & Aoussat, A. (2018). Standardised evaluation of medicine acceptability in paediatric population: Reliability of a model. The Journal of Pharmacy and Pharmacology, 70, 42–50.
Article
CAS
PubMed
Google Scholar
Kozarewicz, P. (2014). Regulatory perspectives on acceptability testing of dosage forms in children. International Journal of Pharmaceutics, 469, 245–248.
Article
CAS
PubMed
Google Scholar
Turner, M. A., Catapano, M., Hirschfeld, S., & Giaquinto, C. (2014). Paediatric drug development: The impact of evolving regulations. Advanced Drug Delivery Reviews, 73, 2–13.
Article
CAS
PubMed
Google Scholar
Davies, E. H., & Tuleu, C. (2008). Medicines for children: A matter of taste. The Journal of Pediatrics, 153, 599–604.
Article
PubMed
Google Scholar
Liu, F., Ranmal, S., Batchelor, H. K., Orlu-Gul, M., Ernest, T. B., Thomas, I. W., … Tuleu, C. (2015). Formulation factors affecting acceptability of oral medicines in children. International Journal of Pharmaceutics, 492, 341–343.
Article
CAS
PubMed
Google Scholar
Ranmal, S. R., O'Brien, F., Lopez, F., Ruiz, F., Orlu, M., Tuleu, C., … Liu, F. (2018). Methodologies for assessing the acceptability of oral formulations among children and older adults: A systematic review. Drug Discovery Today, 23, 830–847.
Article
PubMed
Google Scholar
Squires, L., Lombardi, D., Sjostedt, P., & Thompson, C. (2013). A systematic literature review on the assessment of palatability and swallowability in the development of oral dosage forms for pediatric patients. Therapeutic Innovation & Regulatory Science, 47, 533–541.
Article
Google Scholar
van Riet-Nales, D. A., Schobben, A. F., Egberts, T. C., & Rademaker, C. M. (2010). Effects of the pharmaceutical technologic aspects of oral pediatric drugs on patient-related outcomes: A systematic literature review. Clinical Therapeutics, 32, 924–938.
Article
PubMed
Google Scholar
Lopez, F. L., Ernest, T. B., Tuleu, C., & Gul, M. O. (2015). Formulation approaches to pediatric oral drug delivery: Benefits and limitations of current platforms. Expert Opinion on Drug Delivery, 12, 1727–1740.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mistry, P., & Batchelor, H. (2017). Methodology used to assess acceptability of oral pediatric medicines: A systematic literature search and narrative review. Paediatric Drugs, 19, 223–233.
Article
PubMed
Google Scholar
Ternik, R., Liu, F., Bartlett, J. A., Khong, Y. M., Thiam Tan, D. C., Dixit, T., … Klein, S. (2018). Assessment of swallowability and palatability of oral dosage forms in children: Report from an m-cersi pediatric formulation workshop. International Journal of Pharmaceutics, 536, 570–581.
Article
CAS
PubMed
Google Scholar
Thompson, C., Lombardi, D., Sjostedt, P., & Squires, L. (2015). Best practice recommendations regarding the assessment of palatability and swallowability in the development of oral dosage forms for pediatric patients. Therapeutic Innovation & Regulatory Science, 49, 647–658.
Article
Google Scholar
Patrick, D. L., Burke, L. B., Gwaltney, C. J., Leidy, N. K., Martin, M. L., Molsen, E., & Ring, L. (2011). Content validity – Establishing and reporting the evidence in newly developed patient-reported outcomes (pro) instruments for medical product evaluation: Ispor pro good research practices task force report: Part 1 – Eliciting concepts for a new pro instrument. Value in Health, 14, 967–977.
Article
PubMed
Google Scholar
Patrick, D. L., Burke, L. B., Gwaltney, C. J., Leidy, N. K., Martin, M. L., Molsen, E., & Ring, L. (2011). Content validity – Establishing and reporting the evidence in newly developed patient-reported outcomes (pro) instruments for medical product evaluation: Ispor pro good research practices task force report: Part 2 – Assessing respondent understanding. Value in Health, 14, 978–988.
Article
PubMed
Google Scholar
Brown School of Public Health. (Center for evidence synthesis in health. Https://www.Brown.Edu/academics/public-health/research/evidence-synthesis-in-health/research-initiatives/software-0. Accessed 22 May 2018.
Abdulla, S., Amuri, B., Kabanywanyi, A. M., Ubben, D., Reynolds, C., Pascoe, S., et al. (2010). Early clinical development of artemether-lumefantrine dispersible tablet: Palatability of three flavours and bioavailability in healthy subjects. Malaria Journal, 9, 253.
Article
PubMed
PubMed Central
CAS
Google Scholar
Adams, L. V., Craig, S. R., Mmbaga, E. J., Naburi, H., Lahey, T., Nutt, C. T., … Spielberg, S. P. (2013). Children's medicines in Tanzania: A national survey of administration practices and preferences. PLoS One, 8, e58303.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baguley, D., Lim, E., Bevan, A., Pallet, A., & Faust, S. N. (2012). Prescribing for children – Taste and palatability affect adherence to antibiotics: A review. Archives of Disease in Childhood, 97, 293–297.
Article
PubMed
Google Scholar
Bradshaw, H., Mitchell, M. J., Edwards, C. J., Stolz, U., Naser, O., Peck, A., & Patanwala, A. E. (2016). Medication palatability affects physician prescribing preferences for common pediatric conditions. Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 23, 1243–1247.
Article
Google Scholar
Cohen, R., de La Rocque, F., Lecuyer, A., Wollner, C., Bodin, M. J., & Wollner, A. (2009). Study of the acceptability of antibiotic syrups, suspensions, and oral solutions prescribed to pediatric outpatients. European Journal of Pediatrics, 168, 851–857.
Article
PubMed
Google Scholar
Fine, B., Castillo, R., McDonald, T., Paisansathan, C., Zsigmond, E., & Hoffman, W. E. (2004). Jet injector compared with oral midazolam for preoperative sedation in children. Paediatric Anaesthesia, 14, 739–743.
Article
PubMed
Google Scholar
Gee, S. C., & Hagemann, T. M. (2007). Palatability of liquid anti-infectives: Clinician and student perceptions and practice outcomes. Journal of Pediatric Pharmacology and Therapeutics, 12, 216–223.
Google Scholar
Hansen, D. L., Tulinius, D., & Hansen, E. H. (2008). Adolescents’ struggles with swallowing tablets: Barriers, strategies and learning. Pharmacy World & Science, 30, 65–69.
Article
Google Scholar
Ivanovska, V., Rademaker, C. M., van Dijk, L., & Mantel-Teeuwisse, A. K. (2014). Pediatric drug formulations: A review of challenges and progress. Pediatrics, 134, 361–372.
Article
PubMed
Google Scholar
Jagani, M., Legay, H., Ranmal, S. R., Bertrand, J., Ooi, K., & Tuleu, C. (2016). Can a flavored spray (pill glide) help children swallow their medicines? A pilot study. Pediatrics, 138, e20160680.
Article
PubMed
Google Scholar
Kayumba, P. C., Huyghebaert, N., Cordella, C., Ntawukuliryayo, J. D., Vervaet, C., & Remon, J. P. (2007). Quinine sulphate pellets for flexible pediatric drug dosing: Formulation development and evaluation of taste-masking efficiency using the electronic tongue. European Journal of Pharmaceutics and Biopharmaceutics, 66, 460–465.
Article
CAS
PubMed
Google Scholar
Klingmann, V. (2017). Acceptability of mini-tablets in young children: Results from three prospective cross-over studies. AAPS PharmSciTech, 18, 263–266.
Article
PubMed
Google Scholar
Klingmann, V., Spomer, N., Lerch, C., Stoltenberg, I., Fromke, C., Bosse, H. M., … Meissner, T. (2013). Favorable acceptance of mini-tablets compared with syrup: A randomized controlled trial in infants and preschool children. The Journal of Pediatrics, 163, 1728–1732.
Article
PubMed
Google Scholar
Kraus, D. M., Stohlmeyer, L. A., Hannon, P. R., & Freels, S. A. (2001). Effectiveness and infant acceptance of the rx medibottle versus the oral syringe. Pharmacotherapy, 21, 416–423.
Article
CAS
PubMed
Google Scholar
Kraus, D. M., Stohlmeyer, L. A., & Hannon, P. R. (1999). Infant acceptance and effectiveness of a new oral liquid medication delivery system. American Journal of Health-System Pharmacy, 56, 1094–1101.
Article
CAS
PubMed
Google Scholar
Mennella, J. A., & Beauchamp, G. K. (2008). Optimizing oral medications for children. Clinical Therapeutics, 30, 2120–2132.
Article
PubMed
PubMed Central
Google Scholar
Mennella, J. A., Roberts, K. M., Mathew, P. S., & Reed, D. R. (2015). Children's perceptions about medicines: Individual differences and taste. BMC Pediatrics, 15, 130.
Article
PubMed
PubMed Central
Google Scholar
Monteagudo, E., Langenheim, M., Salerno, C., Buontempo, F., Bregni, C., & Carlucci, A. (2014). Pharmaceutical optimization of lipid-based dosage forms for the improvement of taste-masking, chemical stability and solubilizing capacity of phenobarbital. Drug Development and Industrial Pharmacy, 40, 783–792.
Article
CAS
PubMed
Google Scholar
Mulla, H., Buck, H., Price, L., Parry, A., Bell, G., & Skinner, R. (2016). 'Acceptability' of a new oral suspension formulation of mercaptopurine in children with acute lymphoblastic leukaemia. Journal of Oncology Pharmacy Practice, 22, 387–395.
Article
CAS
PubMed
Google Scholar
Purswani, M. U., Radhakrishnan, J., Irfan, K. R., Walter-Glickman, C., Hagmann, S., & Neugebauer, R. (2009). Infant acceptance of a bitter-tasting liquid medication: A randomized controlled trial comparing the rx medibottle with an oral syringe. Archives of Pediatrics & Adolescent Medicine, 163, 186–188.
Article
Google Scholar
Raja Shekhar, S., & Vehavathi, T. (2012). Recent trends of oral fast disintegrating tablets – An overview of formulation and taste masking technology. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 3, 771–792.
CAS
Google Scholar
Rouse, C., Mistry, P., Rayner, O., Nickless, J., Wan, M., Southern, K. W., & Batchelor, H. K. (2017). A mixed methods study of the administration of flucloxacillin oral liquid; identifying strategies to overcome administration issues of medicines with poor palatability. The International Journal of Pharmacy Practice, 25, 326–334.
Article
PubMed
Google Scholar
Spomer, N., Klingmann, V., Stoltenberg, I., Lerch, C., Meissner, T., & Breitkreutz, J. (2012). Acceptance of uncoated mini-tablets in young children: Results from a prospective exploratory cross-over study. Archives of Disease in Childhood, 97, 283–286.
Article
PubMed
Google Scholar
van Riet-Nales, D. A., de Neef, B. J., Schobben, A. F., Ferreira, J. A., Egberts, T. C., & Rademaker, C. M. (2013). Acceptability of different oral formulations in infants and preschool children. Archives of Disease in Childhood, 98, 725–731.
Article
PubMed
Google Scholar
van Riet-Nales, D. A., Ferreira, J. A., Schobben, A. F., de Neef, B. J., Egberts, T. C., & Rademaker, C. M. (2015). Methods of administering oral formulations and child acceptability. International Journal of Pharmaceutics, 491, 261–267.
Article
PubMed
CAS
Google Scholar
van Riet-Nales, D. A., Schobben, A. F., Vromans, H., Egberts, T. C., & Rademaker, C. M. (2016). Safe and effective pharmacotherapy in infants and preschool children: Importance of formulation aspects. Archives of Disease in Childhood, 101, 662–669.
Article
PubMed
Google Scholar
Venables, R., Stirling, H., Batchelor, H., & Marriott, J. (2015). Problems with oral formulations prescribed to children: A focus group study of healthcare professionals. International Journal of Clinical Pharmacy, 37, 1057–1067.
Article
PubMed
Google Scholar
Walsh, J., Cram, A., Woertz, K., Breitkreutz, J., Winzenburg, G., Turner, R., & Tuleu, C. (2014). Playing hide and seek with poorly tasting paediatric medicines: Do not forget the excipients. Advanced Drug Delivery Reviews, 73, 14–33.
Article
CAS
PubMed
Google Scholar
Winzenburg, G., & Desset-Brethes, S. (2012). Industry perspective on palatability testing in children–two case studies. International Journal of Pharmaceutics, 435, 139–142.
Article
CAS
PubMed
Google Scholar
Tuleu C. (2011) Acceptability and palatability – methods available for assessment. Available from: Http://www.Ema.Europa.Eu/docs/en_gb/document_library/presentation/2012/01/wc500121607.Pdf. Workshop on Paediatric Formulations II for Assessors in National Regulatory Agencies. Accessed 13 Aug 2018.
Google Scholar
Matza, L. S., Patrick, D. L., Riley, A. W., Alexander, J. J., Rajmil, L., Pleil, A. M., & Bullinger, M. (2013). Pediatric patient-reported outcome instruments for research to support medical product labeling: Report of the ispor pro good research practices for the assessment of children and adolescents task force. Value in Health, 16, 461–479.
Article
PubMed
Google Scholar
Ranmal, S., & Tuleu, C. (2013). Demonstrating evidence of acceptability: The “catch-22” of pediatric formulation development. Clinical Pharmacology and Therapeutics, 94, 582–584.
Article
CAS
PubMed
Google Scholar
Mistry, P., Stirling, H., Callens, C., Hodson, J., & Batchelor, H. (2018). Evaluation of patient-reported outcome measurements as a reliable tool to measure acceptability of the taste of paediatric medicines in an inpatient paediatric population. BMJ Open, 8, e021961.
Article
PubMed
PubMed Central
Google Scholar
Turner-Bowker, D. M., Lamoureux, R. E., Stokes, J., Litcher-Kelly, L., Galipeau, N., Yaworsky, A., … Shields, A. L. (2018). Informing a priori sample size estimation in qualitative concept elicitation interview studies for clinical outcome assessment instrument development. Value in Health, 21, 839–842.
Article
PubMed
Google Scholar