Using PROMIS-29 to determine symptom burdens in the context of the Type 1 and 2 systemic lupus erythematosus (SLE) model: a cross sectional study

Journal of Patient-Reported Outcomes

Table 2 PROMIS-29 T-scores by Type 1 and 2 SLE categorization

PROMIS domains, median (IQR)	Overall (n = 120)	Minimal (n = 43)	Type 1 (n = 12)	Type 2 (n = 31)	Mixed (n = 34)	p value
Depression	41^a (41–54)	41 (41–52)	41 (41–45)	46 (41–54)	51 (41–56)	0.05
Anxiety	51 (40–58)	48 (40–56)	46 (40–56)	54 (40–60)	53 (49–60)	0.04
Social Function	50 (42–58)	52 (50–64)	55 (48–61)	44 (39–50)	44 (40–52)	< 0.0001
Fatigue	56 (49–64)	49 (43–53)	50 (34–55)	*63 (57–69)*	*63 (57–70)*	< 0.0001
Sleep Disturbance	56 (54–59)	54 (51–58)	57 (56–59)	57 (54–61)	56 (54–59)	0.03
Pain interference	56 (50–61)	52 (42–56)	56 (42–59)	*61 (56–67)*	*61 (56–67)*	< 0.0001
Physical Function	42 (37–57)	57 (43–57)	43 (39–47)	*39 (34–43)*	*39 (35–43)*	< 0.0001

PROMIS T-score means are 50 for the reference population, with a difference of 5 (half standard deviation) representing a clinically significant difference [29, 30]. A higher score indicates more of the domain being measured. Depression, anxiety, sleep disturbance, fatigue, and pain interference: higher score indicates worse problem. Social and physical functioning: lower score indicates worse problem. p values are generated using the Kruskal–Wallis test to compare PROMIS T-scores across Type 1 and 2 SLE categorization groups.
^aThe mean Depression T-score was 47.8 (SD 8.4) with more than half of the participants scoring 40–45
Italic: Better than general population (T-score ≥ 5 points better than mean of 50)
Bold: Same as general population (T-score between 45 and 55)
Underline: Worse than general population (T-score ≥ 5 but < 10 points worse than mean of 50)
Bold and italic: Much worse than general population (≥ 10 points worse than mean of 50)
PROMIS patient-reported outcome measurement information system, SRA social roles and activities