Table 4 Summary of key measurement properties of the EoE-IQ at baseline and week 24

Construct validity: convergent and divergent validity

Pearson correlation coefficient (n) at baseline/week 24

DSQ

0.44 (224)

0.68 (175)

EoE-SQ Frequency

0.56 (224)

0.72 (212)

EoE-SQ Severity

0.54 (224)

0.61 (212)

PGIS

0.60 (224)

0.67 (212)

EoE-EREFS

–0.10 (224)

0.20 (207)

Peak esophageal intraepithelial eosinophil count

Not conducted^a

0.15 (208)

Categorized peak esophageal intraepithelial eosinophil count

Not conducted^a

0.09 (208)

Construct validity: known-groups validity

Mean score (n) per known group at baseline/week 24

PGIS

None: 1.09 (1)

None: 1.15 (66)

Mild: 1.82 (99)

Mild: 1.52 (107)

Moderate: 2.52 (104)

Moderate: 2.29 (32)

Severe: 3.25 (20)

Severe: 2.99 (7)

P < 0.0001

P < 0.0001

Categorized peak esophageal intraepithelial eosinophil count

≤ 6 eos/hpf: not conducted^a

≤ 6 eos/hpf: 1.49 (97)

> 6 to < 15 eos/hpf: not conducted^a

> 6 to < 15 eos/hpf: 1.54 (30)

≥ 15 eos/hpf: not conducted^a

≥ 15 eos/hpf: 1.61 (81)

P = not conducted^a

P = 0.4556

Ability to detect change: responsiveness and interpretation of change

EoE-IQ change by PGIS change between baseline and week 24

Mean change score (n)

–

Improved: –0.863 (121)

–

No change: − 0.394 (65)

–

Worsened: 0.062 (12)

–

P < 0.0001

EoE-IQ change by PGIC at week 24

Mean change score (n)

–

Better: − 0.780 (160)

–

No change: − 0.231 (29)

–

Worse: 0.251 (9)

–

P < 0.0001

Pearson correlation of change coefficient (n) at week 24

DSQ

–

0.46 (162)

EoE-SQ Frequency

–

0.53 (198)

EoE-SQ Severity

–

0.42 (198)

PGIS

–

0.55 (198)

PGIC

–

0.44 (198)

EoE-EREFS

–

0.04 (194)

Peak esophageal intraepithelial eosinophil count

–

0.07 (195)

Categorized peak esophageal intraepithelial eosinophil count

–

0.03 (195)