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Table 8 Comparison between baseline patient demographic and disease characteristics of PRO cohort and non-PRO cohort

From: Performance of the FACT-GOG-Ntx to assess chemotherapy-induced peripheral neuropathy (CIPN) in pediatric high risk Hodgkin lymphoma: report from the Children’s Oncology Group AHOD 1331 study

 

Total, n = 587

PRO Cohort, n = 309

Non-PRO Cohort n = 278

P-valuea

Age in years, mean (SD)

15.03 (3.10)

14.99 (2.74)

15.08 (3.46)

0.73

Categorical age in years, n (%)

   

0.15

 2 to 4.9

4 (0.68)

0 (0.00)

4 (1.44)

 

 5 to 10.9

58 (9.88)

29 (9.39)

29 (10.43)

 

 11 to 14.9

176 (29.98)

98 (31.72)

78 (28.06)

 

 15 to 21.9

349 (59.45)

182 (58.90)

167 (60.07)

 

Sex, n (%)

   

0.08

 Female

276 (47.02)

156 (50.49)

120 (43.17)

 

 Male

311 (52.98)

153 (49.51)

158 (56.83)

 

Race/Ethnicity, n (%)

   

0.23

 Hispanic

119 (20.27)

54 (17.48)

65 (23.38)

 

 Non-Hispanic Black

59 (10.05)

31 (10.03)

28 (10.07)

 

 Non-Hispanic White

338 (57.58)

189 (61.17)

149 (53.60)

 

 Other and Unknown

71 (12.10)

35 (11.33)

36 (12.95)

 

Histology, n (%)

   

0.48

 Nodular sclerosis

449 (76.49)

240 (77.67)

209 (75.18)

 

 Mixed cellularity

33 (5.62)

13 (4.21)

20 (7.19)

 

 NOS

98 (16.70)

52 (16.83)

46 (16.55)

 

 Lymphocyte-rich

7 (1.19)

4 (1.29)

3 (1.08)

 

Stage, n (%)

   

0.19

 Stage IIB with Bulk

121 (20.61)

67 (21.68)

54 (19.42)

 

 Stage III

113 (19.25)

63 (20.39)

50 (17.99)

 

 Stage IVA

167 (28.45)

76 (24.60)

91 (32.73)

 

 Stage IVB

186 (31.69)

103 (33.33)

83 (29.86)

 

B symptoms, n (%)

   

0.13

 No

162 (27.60)

75 (24.27)

87 (31.29)

 

 Yes

418 (71.21)

231 (74.76)

187 (67.27)

 

 Unknown

7 (1.19)

3 (0.97)

4 (1.44)

 

Bulkb, n (%)

   

0.29

 No

172 (29.30)

82 (26.54)

90 (32.37)

 

 Yes

411 (70.02)

225 (72.82)

186 (66.91)

 

 Unknown

4 (0.68)

2 (0.65)

2 (0.72)

 

Large mediastinal mass (LMA)b, n (%)

   

0.15

 No

263 (44.80)

128 (41.42)

135 (48.56)

 

 Yes

323 (55.03)

180 (58.25)

143 (51.44)

 

 Unknown

1 (0.17)

1 (0.32)

0 (0.00)

 

Bone marrow disease, n (%)

   

0.75

 No

497 (84.67)

263 (85.11)

234 (84.17)

 

 Yes

90 (15.33)

46 (14.89)

44 (15.83)

 
  1. ap-values compare PRO Cohort and Non-PRO Cohort
  2. bBulk is defined as LMA (transverse tumor diameter > 1/3 the thoracic diameter at the dome of the diaphragm on a 6-foot posterior-anterior upright chest radiograph) or extra-mediastinal bulk (a continuous aggregate of nodal tissue outside the mediastinum that measures > 6 cm in transverse dimension on axial CT or longest dimension on coronal or sagittal reformatted CT)