Performance of the FACT-GOG-Ntx to assess chemotherapy-induced peripheral neuropathy (CIPN) in pediatric high risk Hodgkin lymphoma: report from the Children’s Oncology Group AHOD 1331 study

Journal of Patient-Reported Outcomes

Table 2 FACT-GOG-Ntx and CHRIs-global mean summary scores by rater over time

Mean (SD), n	Time 1 (Baseline)	Time 2 (D8, Cycle 2)	Time 3 (D8, Cycle 5)
CIPN
FACT-GOG-Ntx, mean (SD)
Youth	40.6 (4.2), n = 266	39.6 (4.9), n = 265	37.9 (6.9), n = 255
Parent-Proxy	40.9 (3.9), n = 280	40.2 (4.6), n = 278	38.1 (7.5), n = 264
FACT-GOG-Ntx-4, mean (SD)
Youth	15.3 (1.7), n = 266	14.5 (2.4), n = 265	13.5 (3.4), n = 255
Parent-Proxy	15.3 (1.8), n = 280	14.6 (2.4), n = 278	13.6 (3.6), n = 264
HRQL
CHRIs-Global, mean (SD)
Youth	67.6 (22.1), n = 259	71.8 (20.8), n = 258	72.2 (22.2), n = 249
Parent-Proxy	62.2 (23.8), n = 274	66.3 (21.0), n = 269	66.7 (22.6), n = 256

CIPN, Chemotherapy-induced peripheral neuropathy. FACT-GOG-Ntx scores can range from 0 to 44 with higher scores indicating less symptoms.FACT-GOG-Ntx-4 sensory subscale score can range from 0 to 16 with higher scores indicating less symptoms. CHRIs-Global scores can range from 0 to 100 with higher scores indicating better HRQL. Youth report is for patients aged 11–21.9 years; parent-proxy report is for youth aged 5–17.9 years