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Journal of Patient-Reported Outcomes
Fig. 4 | Journal of Patient-Reported Outcomes

Fig. 4

From: Use of patient-reported outcomes (PRO) data to complement exposure–response analysis in early clinical cancer drug development

Fig. 4

Heatmap of show frequency of PR-diarrhea (LWS) in different AUC quantiles. Longitudinal PR-diarrhea frequency assessed over time versus AUC exposure. The PR-diarrhea frequency over time by heatmap was shown as the whole patient population (A) and stratified by drug exposure as AUCs quantile bins (B) at individual level. Each line indicates one patient record of PR-diarrhea evaluation. White box indicates a missing observation. Larger areas of orange and red were shown in patients with higher drug exposure (AUCs Q3 andQ4 versus Q1 and Q2)

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