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Journal of Patient-Reported Outcomes
Fig. 2 | Journal of Patient-Reported Outcomes

Fig. 2

From: Use of patient-reported outcomes (PRO) data to complement exposure–response analysis in early clinical cancer drug development

Fig. 2

A Probability of CR-diarrhea with increasing exposure. B Probability of PR-diarrhea with increasing exposure. Observed and model predicated probability of A CR-diarrhea or B PR-diarrhea versus AUCss of study drug in the subgroup of 120 patients who completed both CTCAE and PRO-CTCAE assessments. Circles indicate the observed event (present = 1, absent = 0); vertical bars represent the observed probability of diarrhea) in AUC quartile groups; the line and the corresponding band stands for the population probability for diarrhea by logistic regression and its 95% confidence interval. The logistic regression model for CR-diarrhea A is logit(P(Y = 1) =  − 0 .734_ + 2.499e−05*AUCs, p = 0.49; and the model for PR-diarrhea  ≥ 3 is logit(P(Y = 1) = − 0.219_ + 8.992–05*AUCs, p = 0.028

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