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Journal of Patient-Reported Outcomes
Fig. 1 | Journal of Patient-Reported Outcomes

Fig. 1

From: Use of patient-reported outcomes (PRO) data to complement exposure–response analysis in early clinical cancer drug development

Fig. 1

ER analysis of diarrhea with the 750-patient dataset by logistic regression. Observed and model predicated probability of diarrhea occurrence versus AUCs in the complete trial population. CR-diarrhea assessments were available for 750 patients in the ER analysis. Circles indicates the observed diarrhea event (present = 1, absent = 0); vertical bars represent the observed probability of diarrhea in AUC quantile groups; the line and the corresponding band stands for the population probability by logistic regression (logit(P(Y = 1) = − 0.526_ + 2.154e−05*AUCs, p = 0.004) and its 95% confidence interval

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