The reliability and validity of the TBI-CareQOL system in four diverse caregiver groups

Carlozzi, Noelle E.; Choi, Sung Won; Wu, Zhenke; Sen, Srijan; Troost, Jonathan; Lyden, Angela K.; Miner, Jennifer A.; Graves, Christopher; Sander, Angelle M.

doi:10.1186/s41687-023-00602-x

Journal of Patient-Reported Outcomes

Table 3 Convergent and discriminant validity

From: The reliability and validity of the TBI-CareQOL system in four diverse caregiver groups

HRQOL measure	Convergent validity	Discriminant validity
HRQOL measure	Convergent validity	CAS ideology	CAS mastery
Caregivers of persons with spinal cord injury (n = 19)
Caregiver-specific HRQOL
TBI-CareQOL caregiver-specific anxiety	CAS Burden − 0.82*	0.47*	− 0.11
TBI-CareQOL caregiver strain	CAS Burden − 0.78*	0.20	− 0.01
Mental HRQOL
Neuro-QoL anxiety SF	PROMIS GLOBAL Mental Health − 0.46*	0.23	− 0.17
Neuro-QoL depression SF	PROMIS GLOBAL Mental Health − 0.70*	0.17	− 0.18
PROMIS anger SF	PROMIS GLOBAL Mental Health − 0.71*	0.20	− 0.24
Neuro-QoL positive affect and well being SF	PROMIS GLOBAL Mental Health 0.78*	− 0.24	0.07
NIH toolbox self-efficacy SF	Neuro-QoL Positive Affect and Well-Being 0.72*	− 0.22	− 0.08
NIH toolbox perceived stress SF	CAS Burden − 0.66	0.10	− 0.19
Social HRQOL
Neuro-QoL ability to participate in SRA SF	CAS Burden 0.62*	− 0.13	0.13
Physical HRQOL
PROMIS sleep related impairment SF	PROMIS GLOBAL Physical Health − 0.54*	− 0.01	− 0.10
PROMIS fatigue SF	PROMIS GLOBAL Physical Health − 0.70*	0.12	− 0.12
Caregivers of persons with Huntington disease (n = 21)
Caregiver-specific HRQOL
TBI-CareQOL caregiver-specific anxiety	CAS Burden − 0.66*	0.12	− 0.31
TBI-CareQOL caregiver strain	CAS Burden − 0.78*	0.41	− 0.29
Mental HRQOL
Neuro-QoL anxiety SF	PROMIS GLOBAL Mental Health − 0.81*	0.24	− 0.16
Neuro-QoL depression SF	PROMIS GLOBAL Mental Health − 0.92*	0.24	− 0.19
PROMIS anger SF	PROMIS GLOBAL Mental Health − 0.80*	0.13	− 0.18
Neuro-QoL Positive affect and well being SF	PROMIS GLOBAL Mental Health 0.85*	− 0.005	0.37
NIH toolbox self-efficacy SF	Neuro-QoL Positive Affect and Well-Being 0.69*	0.22	0.34
NIH toolbox perceived stress SF	CAS Burden − 0.82*	0.13	− 0.31
Social HRQOL
Neuro-QoL ability to participate in SRA SF	CAS Burden 0.66*	− 0.34	0.14
Physical HRQOL
PROMIS sleep related impairment SF	PROMIS GLOBAL Physical Health − 0.69*	− 0.10	− 0.51*
PROMIS fatigue SF	PROMIS GLOBAL Physical Health − 0.73*	0.10	− 0.46*
Caregivers of persons with HCT (n = 30)
Caregiver-specific HRQOL
TBI-CareQOL caregiver-specific anxiety	CAS Burden − 0.84*	− 0.38*	− 0.05
TBI-CareQOL caregiver strain	CAS Burden − 0.77*	− 0.20	− 0.14
Mental HRQOL
Neuro-QoL anxiety SF	PROMIS GLOBAL Mental Health − 0.50*	− 0.08	0.06
Neuro-QoL depression SF	PROMIS GLOBAL Mental Health − 0.42*	− 0.17	− 0.03
PROMIS anger SF	PROMIS GLOBAL Mental Health − 0.47*	− 0.10	− 0.19
Neuro-QoL positive affect and well being SF	PROMIS GLOBAL Mental Health 0.77*	0.43*	− 0.11
NIH toolbox self-efficacy SF	Neuro-QoL Positive Affect and Well-Being 0.72*	0.07	0.07
NIH toolbox perceived stress SF	CAS Burden − 0.78*	− 0.27	0.03
Social HRQOL
Neuro-QoL ability to participate in SRA SF	CAS Burden 0.65*	0.24	0.29
Physical HRQOL
PROMIS sleep related impairment SF	PROMIS GLOBAL Physical Health − 0.50*	− 0.12	− 0.29
PROMIS fatigue SF	PROMIS GLOBAL Physical Health − 0.60*	− 0.24	− 0.13
Caregivers of Persons with Traumatic Brain Injury (n = 139)
Caregiver-specific HRQOL
TBI-CareQOL caregiver-specific anxiety	CAS Burden − 0.73*	− 0.05	− 0.20*
TBI-CareQOL caregiver strain	CAS Burden − 0.73*	− 0.02	− 0.30*
Mental HRQOL
Neuro-QoL anxiety SF	PROMIS GLOBAL Mental Health − 0.64*	0.09	− 0.26*
Neuro-QoL depression SF	PROMIS GLOBAL Mental Health − 0.62	− 0.03	− 0.29
PROMIS anger SF	PROMIS GLOBAL Mental Health − 0.63*	− 0.03	− 0.26*
Neuro-QoL positive affect and well being SF	PROMIS GLOBAL Mental Health 0.75*	0.03	0.22*
NIH toolbox self-efficacy SF	Neuro-QoL Positive Affect and Well-Being 0.50*	− 0.07	0.24*
NIH toolbox perceived stress SF	CAS Burden − 0.51*	0.02	− 0.26*
Social HRQOL
Neuro-QoL ability to participate in SRA SF	CAS Burden 0.64*	− 0.03	0.21*
Physical HRQOL
PROMIS sleep related impairment SF	PROMIS GLOBAL Physical Health − 0.52*	− 0.01	− 0.22*
PROMIS fatigue SF	PROMIS GLOBAL Physical Health − 0.57*	0.03	− 0.22*

PROMIS Patient Reported Outcomes Measurement Information System; Neuro-QoL Quality of Life in Neurological Disorders; TBI-CareQOL Traumatic Brain Injury Caregiver Quality of Life; NIH National Institutes of Health Toolbox, CAS Caregiver Appraisal Scale, SF = Short Form
*p > 0.05

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