Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple sclerosis

Journal of Patient-Reported Outcomes

Table 3 Correlation coefficients between the anchor variables and the corresponding PRO scores at baseline

Score	N	Anchor variables
Score	N	PDDS^a	MSPS Fatigue item^a	MSPS Cognition item^a
MSIS-29 v2 physical impact score	429	0.81	–	–
MSIS-29 v2 psychological impact score	429	0.38	–	–
MSPS total score	429	0.76	–	–
FSMC physical fatigue score	429	–	0.80	–
FSMC cognitive fatigue score	429	–	0.72	–
FSMC total score	429	–	0.78	–
MSNQ total score	429	–	–	0.75

FSMC Fatigue Scale for Motor and Cognitive Functions; MSIS-29 v2 Multiple Sclerosis Impact Scale 29 items version 2; MSNQ Multiple Sclerosis Neuropsychological Screening Questionnaire; MSPS Multiple Sclerosis Performance Scale; PDDS Patient-Determined Disease Steps; PRO Patient-reported outcome
^aSpearman’s rank-order correlation coefficient. Values in bold represent correlation coefficients of > 0.7