Table 2 Baseline characteristics and PRO scores
Variable | Total (N = 434) |
|---|---|
Age, years, mean (SD) | 50.2 (10.5) |
Female gender, n (%) | 336 (77.4) |
Race, n (%) | |
White | 375 (86.4) |
Black | 36 (8.3) |
Hispanic | 20 (4.6) |
Othera | 3 (0.7) |
Prior MS therapy, n (%) | 353 (81.3) |
Time since first diagnosis of MSb, years, mean (SD) | 11.2 (9.9) |
Time since last MS relapsec, months, mean (SD) | 31.1 (50.5) |
Number of MS relapses in the last year, mean (SD) | 1.5 (2.1) |
0, n (%) | 165 (38.0) |
1, n (%) | 122 (28.1) |
2, n (%) | 64 (14.7) |
≥ 3, n (%) | 83 (19.1) |
Mean (SD) | Median (min, max) | ||
|---|---|---|---|
Multi-item PRO scores | |||
MSIS-29 v2 | Physical impact (n = 429) | 36.6 (25.4) | 33.3 (0, 100) |
Psychological impact (n = 429) | 41.0 (24.8) | 40.7 (0, 100) | |
FSMC | Physical fatigue (n = 429) | 31.8 (11.1) | 34.0 (10, 50) |
Cognitive fatigue (n = 429) | 29.3 (11.2) | 30.0 (10, 50) | |
Total score (n = 429) | 61.1 (21.6) | 64.0 (20, 100) | |
MSPS | Total (n = 429) | 12.5 (7.0) | 12.0 (0, 31) |
MSNQ | Total (n = 429) | 24.1 (13.2) | 23.0 (0, 60) |
TSQM v1.4 | Side effects (n = 353) | 78.9 (28.6) | 100.0 (0, 100) |
Effectiveness (n = 353) | 61.8 (20.0) | 67.0 (0, 100) | |
Convenience (n = 353) | 83.4 (21.6) | 94.0 (0, 100) | |
Global satisfaction (n = 353) | 60.0 (24.5) | 57.0 (0, 100) | |
HADS | Anxiety (n = 429) | 8.1 (4.4) | 8.0 (0, 19) |
Depression (n = 429) | 5.6 (4.0) | 5.0 (0, 20) | |
Single-item PRO scores | |||
PDDS | (n = 429) | 2.2 (2.0) | 2.0 (0, 7) |
HRPQ-MS v2 | Lost work absenteeism household (n = 429) | 2.3 (3.8) | 0.0 (0, 25) |
Lost work absenteeism workplace (n = 218) | 1.5 (5.4) | 0.0 (0, 40) | |
Lost work presenteeism household (n = 429) | 2.1 (4.1) | 1.0 (0, 60) | |
Lost work presenteeism workplace (n = 218) | 3.1 (5.0) | 0.0 (0, 32) | |
Lost work total household (n = 429) | 4.4 (6.5) | 2.0 (0, 60) | |
Lost work total workplace (n = 218) | 4.6 (7.9) | 0.0 (0, 40) | |
Percent lost work absenteeism household (n = 429) | 22.0 (29.4) | 0.0 (0, 100) | |
Percent lost work absenteeism workplace (n = 218) | 4.8 (16.5) | 0.0 (0, 100) | |
Percent lost work presenteeism household (n = 429) | 18.9 (22.7) | 13.0 (0, 100) | |
Percent lost work presenteeism workplace (n = 218) | 9.3 (14.7) | 0.0 (0, 80) | |
Percent lost work total household (n = 429) | 41.0 (38.3) | 33.0 (0, 100) | |
Percent lost work total workplace (n = 218) | 14.0 (23.1) | 0.0 (0, 100) | |
Work presenteeism household (n = 429) | 8.6 (8.5) | 6.0 (0, 60) | |
Work presenteeism workplace (n = 218) | 32.8 (13.8) | 40.0 (0, 60) | |