Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple sclerosis

Journal of Patient-Reported Outcomes

Table 1 Patient-reported outcome instruments administered during the PROMiS AUBAGIO study

Instrument	PRO scores			Assessment schedule (# of assessments)
Instrument	Score	Number of items	Score range	Assessment schedule (# of assessments)
Instruments assessed by anchor-based and distribution-based analysis:
MSIS-29 v2	Physical impact	20	0–100	BL, M4, M8, M12 (n = 4)
MSIS-29 v2	Psychological impact	9	0–100	BL, M4, M8, M12 (n = 4)
FSMC	Physical fatigue	10	10–50	BL, M2, M5, M8, M11 (n = 5)
	Cognitive fatigue	10	10–50
	Total	20	20–100
MSPS	Total	8	0–40	BL, M4, M8, M12 (n = 4)
MSNQ	Total	15	0–60	BL, M3, M6, M9, M12 (n = 5)
Instruments assessed by distribution-based analysis only:
TSQM v1.4	Side effects	4	0–100	BL, M1, M4, M7, M10 (n = 5)
	Effectiveness	3	0–100
	Convenience	3	0–100
	Global satisfaction	3	0–100
PDDS		1	0–8	BL, M6, M12 (n = 3)
HRPQ-MS v2		9	Open ended/multiple choice	BL, M1, M5, M8, M11 (n = 5)
HADS	Anxiety	7	0–21	BL, M3, M6, M9, M12 (n = 5)
HADS	Depression	7	0–21	BL, M3, M6, M9, M12 (n = 5)

BL Baseline; FSMC Fatigue Scale for Motor and Cognitive Functions; HADS Hospital Anxiety and Depression Scale; HRPQ-MS v2 Health-Related Productivity Questionnaire in Multiple Sclerosis version 2; M Month x; MSIS-29 v2 Multiple Sclerosis Impact Scale 29 items version 2; MSNQ Multiple Sclerosis Neuropsychological Screening Questionnaire; MSPS Multiple Sclerosis Performance Scale; PDDS Patient-Determined Disease Steps; PRO Patient-reported outcome; TSQM v1.4 Treatment Satisfaction Questionnaire with Medication version 1.4