Evaluation of symptoms in respiratory syncytial virus infection in adults: psychometric evaluation of the Respiratory Infection Intensity and Impact Questionnaire™ symptom scores

Journal of Patient-Reported Outcomes

Table 3 Ability to detect change of the RiiQ™ Symptoms Scale in vaccine trial

Global measure	Correlation, n RiiQ™ Symptoms Scale change score (from ARI PRO eDiary Day 1 to ARI Day 29)
Global measure	Respiratory symptoms	LRT scale	URT scale	Systemic symptoms
Change in PGI-S	0.43, 733	0.37, 733	0.33, 733	0.39, 732
Change in PGI-H	− 0.37, 793	− 0.27, 793	− 0.37, 793	− 0.43, 790
PGI-C	0.22, 829	0.18, 829	0.17, 830	0.15, 829

The PGI-S was scored 0 (I feel fine) to 3 (I feel extremely ill) while the PGI-H was scored 0 (Very poor) to 4 (Very good). The PGI-C was scored − 3 (Much better) to 3 (Much worse). The PGI-H was scored 0 (Very poor) to 4 (Very good)
Pearson correlations were computed with the change in PGI-S and change in PGI-H; polyserial correlations were computed with the PGI-C
hARI acute respiratory infection, LRT lower respiratory tract, PGI-C Patient Global Impression of Change; PGI-H, Patient Global Impression of Health; PGI-S, Patient Global Impression of Severity; PRO, patient-reported outcome; RiiQ™, Respiratory Infection Intensity and Impact Questionnaire; URT, upper respiratory tract