Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis

Journal of Patient-Reported Outcomes

Table 4 Internal consistency and test–retest reliability coefficients for NASH-CHECK scales

NASH-CHECK scale score	Cronbach’s alpha^a	McDonald’s omega^b	ICC (95% CI), n for PGIS stable group^b	ICC (95% CI), n for PGIS stable and placebo group^b
Abdominal pain	–	–	0.65 (0.50–0.76), 77	0.76 (0.54–0.88), 28
Abdominal bloating	–	–	0.80 (0.70–0.87), 77	0.88 (0.76–0.94), 28
Fatigue	–	–	0.70 (0.56–0.80), 77	0.70 (0.44–0.85), 28
Sleep	–	–	0.62 (0.46–0.74), 77	0.66 (0.39–0.83), 28
Itchy skin	–	–	0.40 (0.19–0.57), 77	0.65 (0.37–0.82), 28
Cognitive symptoms	0.92	0.88	0.77 (0.67–0.85), 77	0.84 (0.68–0.92), 28
Activity limitations	0.94	0.91	0.79 (0.68–0.86), 77	0.76 (0.55–0.88), 28
Emotional impact	0.77	0.79	0.68 (0.52–0.79), 77	0.79 (0.60–0.90), 28
Social impact	0.89	0.95	0.90 (0.85–0.94), 77	0.94 (0.88–0.97), 28

CI confidence interval, ICC intraclass correlation coefficient, PGIS Patient Global Impression of Severity
^aCronbach’s coefficient alpha was calculated for the NASH-CHECK multi-item scales at baseline
^bMcDonald’s omega coefficient was calculated for the NASH-CHECK multi-item scales at baseline using the CFA standardized estimates [33, 34]
^bICC was calculated from baseline to week 2 for a stable subsample defined as patients with no change in PGIS (PGIS change = 0) between baseline and week 2