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Journal of Patient-Reported Outcomes

Table 6 Differences in AE-QoL scores at Week 5 between ranked SDS tertile groups of increasing severity for known-groups validity

From: Content validation and psychometric evaluation of the Angioedema Quality of Life Questionnaire for hereditary angioedema

SDS Total (n = 45)

Mean (SD)

AE-QoL total

Functioning

Fatigue/Mood

Fears/Shame

Food

Tertile group

     

    Tertile 1 (n = 15)

19.02 (15.51)

5.83 (11.20)

25.67 (25.35)

23.89 (19.89)

14.17 (17.59)

    Tertile 2 (n = 16)

32.44 (17.17)

26.17 (18.43)

32.50 (19.49)

37.50 (22.00)

29.69 (21.35)

    Tertile 3 (n = 14)

63.13 (17.32)

59.38 (20.62)

59.29 (24.33)

70.83 (22.35)

57.14 (30.51)

ANOVA p value

< 0.0001

< 0.0001

0.0008

< 0.0001

< 0.0001

ANOVA p value (linear trend)

< 0.0001

< 0.0001

0.0003

< 0.0001

< 0.0001

Eta squared,a ɳ2

0.56

0.63

0.29

0.47

0.37

  1. AE-QoL Angioedema Quality of Life Questionnaire, ANOVA analysis of variance, SDS Sheehan Disability Scale
  2. a ɳ2 equal to 0.01 to 0.05 considered a small effect, 0.06 to 0.13 a moderate effect, and 0.14 and over, a large effect [27]
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