Content validation and psychometric evaluation of the Angioedema Quality of Life Questionnaire for hereditary angioedema

Journal of Patient-Reported Outcomes

Table 3 Summary of Cronbach’s alpha with each item deleted for AE-QoL total and domain scores at baseline

AE-QoL item (n = 64)	Cronbach’s alpha with each item deleted (raw^a)
AE-QoL item (n = 64)	Total score	Functioning	Fatigue/Mood	Fears/Shame	Food^b
Item 1 (Impairment of work)	0.91	0.87	-	-	-
Item 2 (Impairment of physical activity)	0.92	0.82	-	-	-
Item 3 (Impairment of spare time activities)	0.91	0.81	-	-	-
Item 4 (Impairment of social relations)	0.92	0.83	-	-	-
Item 5 (General limitations in foods and eating)	0.92	-	-	-	N/A
Item 6 (Difficulties of falling asleep)	0.92	-	0.80	-	-
Item 7 (Waking up during the night)	0.92	-	0.79	-	-
Item 8 (Feeling tired during the day)	0.91	-	0.76	-	-
Item 9 (Difficulties in concentrating)	0.92	-	0.81	-	-
Item 10 (Feeling depressed)	0.92	-	0.83	-	-
Item 11 (Limitations in the selection of food and beverages)	0.92	-	-	-	N/A
Item 12 (Feeling burdened at having swellings)	0.91	-	-	0.86	-
Item 13 (Fear of new suddenly appearing swellings)	0.91	-	-	0.85	-
Item 14 (Fear of increased frequency of swellings)	0.91	-	-	0.84	-
Item 15 (Ashamed to visit public places)	0.91	-	-	0.84	-
Item 16 (Embarrassed by the appearance of swellings)	0.92	-	-	0.85	-
Item 17 (Fear of long-term negative drug effects)	0.92	-	-	0.89	-
Cronbach’s alpha	0.92	0.87	0.83	0.88	0.78

AE-QoL Angioedema Quality of Life Questionnaire
^a All standardized Cronbach’s alpha estimates were consistent with the raw Cronbach’s alpha estimates (i.e., within 0.01)
^b Cronbach’s alpha with each item deleted not calculated for domains with ≤ 2 items