Responsiveness and minimal important change of seven PROMIS computerized adaptive tests (CAT) in patients with advanced chronic kidney disease

Journal of Patient-Reported Outcomes

Table 1 Expected and observed correlations between PROMIS CAT change scores and change scores in SF-12 and DSI

	PROMIS Physical Function	PROMIS Pain Interference	PROMIS Fatigue	PROMIS Sleep Disturbance	PROMIS Anxiety	PROMIS Depression	PROMIS Ability to Participate
PROMIS single item
Pain Intensity (0–10)	-0.22	0.58*	0.28	0.09	0.10	0.14	-0.26
SF-12
Physical functioning	0.39*	-0.26	-0.21	0.00	-0.12	-0.12	0.22
Role-physical	0.44	-0.25	-0.23	-0.17	-0.10	-0.20	0.36*
Bodily pain	0.19	-0.55*	-0.16	-0.06	-0.17	-0.21	0.15
General health	0.31	-0.16	-0.35	-0.11	-0.11	-0.21	0.24
Vitality	0.17	-0.11	-0.41*	-0.10	-0.10	-0.08	0.29
Social functioning	0.22	-0.23	-0.20	-0.06	-0.18	-0.17	0.41*
Role-emotional	0.18	-0.13	-0.12	-0.13	-0.36	-0.36	0.34*
Mental health	0.14	-0.18	-0.18	-0.20	-0.30*	-0.43*	0.27
Physical component summary^*	0.47	-0.45	-0.31	-0.05	-0.04	-0.09	0.24
Mental component summary^*	0.11	-0.10	-0.21	-0.18	-0.37*	-0.40*	0.42
DSI
Number of symptoms (0–30)	-0.35	0.23	0.37	0.29	0.25	0.23	-0.34
Symptom burden score (0-150)	-0.36	0.27	0.38	0.31	0.26	0.26	-0.33
Feeling tired or lack of energy (0–5)	-0.36	0.18	0.41*	0.03	0.11	0.15	-0.20
Sleep problems (0–10)^#	-0.15	0.02	0.14	0.57*	0.02	0.01	-0.20
Feeling anxious (0–5)	-0.06	0.15	0.08	0.12	0.42*	0.29	-0.19
Global Rating Scale
Change in physical function	0.45*	0.25	0.34	0.18	0.11	0.17	0.26
Change in pain	0.29	0.28*	0.27	0.06	0.12	0.11	0.19
Change in fatigue	0.38	0.18	0.37*	0.10	0.03	0.09	0.22
Change in sleep disturbance	0.32	0.12	0.32	0.37*	0.01	0.04	0.14
Change in anxiety	0.24	0.15	0.29	0.24	0.04*	0.11	0.02
Change in depression	0.17	0.13	0.25	0.17	0.05	0.20*	0.07
Change in ability to participate	0.38	0.20	0.32	0.17	0.13	0.22	0.32*

* Expected correlations of at least 0.40
Bold = Per comparator instrument, the PROMIS CAT was expected to have the highest correlations with scales measuring similar domains
Italic = the PROMIS CATs were expected to have higher correlations with these DSI domains than with the other DSI domains (but lower than the bold correlations with similar domains of the other comparator instruments)
^* SF-12 physical component summary includes the domains physical functioning, role-physical, bodily pain and general health; SF-12 mental component summary includes the domains vitality, social functioning, role-emotional and mental health
^# DSI Sleep problems were defined as trouble falling asleep and/or trouble staying asleep
Abbreviations: PROMIS, Patient-Reported Outcomes Measurement Information System; CAT, Computerized Adaptive Test; SF-12, 12-item Short Form Health Survey; DSI, Dialysis Symptom Index