Validation and meaningful within-patient change in work productivity and activity impairment questionnaire (WPAI) for episodic or chronic migraine

Ford, Janet H.; Ye, Wenyu; Ayer, David W.; Mi, Xiaojuan; Bhandari, Swati; Buse, Dawn C.; Lipton, Richard B.

doi:10.1186/s41687-023-00552-4

Journal of Patient-Reported Outcomes

Table 4 ROC analyses for change in WPAI domain scores from baseline to Month 3 (Overall population)

From: Validation and meaningful within-patient change in work productivity and activity impairment questionnaire (WPAI) for episodic or chronic migraine

WPAI	Dependent variable	Cut-off point	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Youden index	Phi coefficient
WPAI presenteeism	Monthly migraine headache days by 50%	−39.96	0.4085	0.9014	0.5800	0.8205	0.3099	0.3523
		−29.97	0.4789	0.8216	0.4722	0.8255	0.3005	0.2991
		−19.98	0.6197	0.7230	0.4272	0.8508	0.3427	0.3087
	MSQ-RFP domain	−30.00	0.4943	0.8528	0.5972	0.7925	0.3470	0.3677
		−20.00	0.6207	0.7513	0.5243	0.8177	0.3720	0.3566
		−10.00	0.7471	0.5888	0.4452	0.8406	0.3360	0.3099
	MSQ-RFR domain	−29.99	0.4875	0.8382	0.5417	0.8066	0.3257	0.3368
		−19.99	0.6625	0.7549	0.5146	0.8508	0.4174	0.3905
		−10.00	0.7250	0.5686	0.3973	0.8406	0.2936	0.2643
WPAI overall work productivity loss	Monthly migraine headache days by 50%	−20.09	0.5541	0.8093	0.5000	0.8406	0.3634	0.3518
		−19.79	0.6216	0.7488	0.4600	0.8519	0.3705	0.3399
		−19.37	0.6216	0.7442	0.4554	0.8511	0.3658	0.3348
	MSQ-RFP domain	−22.17	0.5730	0.8550	0.6375	0.8182	0.4280	0.4416
		−22.02	0.5730	0.8500	0.6296	0.8173	0.4230	0.4348
		−20.12	0.5730	0.8450	0.6220	0.8164	0.4180	0.4281
	MSQ-RFR domain	−20.01	0.6463	0.7778	0.5354	0.8474	0.4241	0.4029
		−19.39	0.6585	0.7729	0.5347	0.8511	0.4315	0.4080
		−19.16	0.6585	0.7681	0.5294	0.8503	0.4267	0.4025
WPAI activity impairment	Monthly migraine headache days by 50%	−29.95	0.5040	0.7555	0.4468	0.7954	0.2595	0.2507
		−19.97	0.6480	0.6270	0.4050	0.8197	0.2750	0.2485
		−9.98	0.8000	0.4796	0.3759	0.8596	0.2796	0.2566
	MSQ-RFP domain	−29.98	0.4901	0.7713	0.5248	0.7459	0.2614	0.2660
		−19.99	0.6358	0.6451	0.4800	0.7746	0.2808	0.2674
		−10.00	0.7815	0.4949	0.4436	0.8146	0.2763	0.2671
	MSQRFR domain	−40.01	0.4296	0.8770	0.6042	0.7787	0.3067	0.3427
		−30.01	0.5630	0.7896	0.5390	0.8053	0.3526	0.3484
		−20.00	0.6741	0.6472	0.4550	0.8197	0.3213	0.2971

Logistic regression was performed with selected anchor as a dependent variable and each WPAI score as an independent variable. Sensitivity, specificity, positive predictive value, negative predictive value, and Phi correlation for change scores above and below the optimal cut-point were provided to show the range of alternative WPAI change score thresholds. WPAI scores are presented as % unit
MSQ Migraine-Specific Quality of Life questionnaire, RFP role function-preventive, RFR role function-restrictive, ROC receiver-operator characteristic, WPAI Work Productivity and Activity Impairment questionnaire

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