Table 3 Change in WPAI from baseline to Month 3 for responders and non-responders (Overall population)
WPAI | Variables | Responder/non-responder | N (%) | LSM change in WPAI domain scores from baseline to month 3 | LSM change difference in WPAI domain scores between non-responder and responder | |||
|---|---|---|---|---|---|---|---|---|
LSM change (SE) | Within group P-value | LSM change difference (SE) | P-value | |||||
WPAI presenteeism | MSQ-RFP domain | Non-responder | 197 (69.4) | −1.211 (1.591) | 0.4472 |  −  |  −  | |
|  |  | Responder | 87 (30.6) | −24.269 (2.396) |  < 0.0001 | 23.058 (2.878) | 0.0000 | |
|  | MSQ-RFR domain | Non-responder | 204 (71.8) | −1.742 (1.569) | 0.2678 |  −  |  −  | |
|  |  | Responder | 80 (28.2) | −24.933 (2.506) |  < 0.0001 | 23.191 (2.957) | 0.0000 | |
|  | Monthly migraine headache days by 50% | Non-responder | 213 (75.0) | −2.450 (1.546) | 0.1142 |  −  |  −  | |
|  |  | Responder | 71 (25.0) | −25.750 (2.678) |  < 0.0001 | 23.300 (3.092) | 0.0000 | |
WPAI overall work productivity loss | MSQ-RFP domain | Non-responder | 200 (69.2) | −1.872 (1.715) | 0.2760 |  −  |  −  | |
|  |  | Responder | 89 (30.8) | −25.459 (2.574) |  < 0.0001 | 23.587 (3.096) | 0.0000 | |
|  | MSQ-RFR domain | Non-responder | 207 (71.6) | −2.246 (1.683) | 0.1830 |  −  |  −  | |
|  |  | Responder | 82 (28.4) | −26.529 (2.674) |  < 0.0001 | 24.283 (3.160) | 0.0000 | |
|  | Monthly migraine headache days by 50% | Non-responder | 215 (74.4) | −3.343 (1.682) | 0.0479 |  −  |  −  | |
|  | Responder | 74 (25.6) | −25.968 (2.868) |  < 0.0001 | 22.626 (3.326) | 0.0000 | ||
WPAI non-work-related activity impairment | MSQ-RFP domain | Non-responder | 293 (66.0) | −7.470 (1.445) |  < 0.0001 |  −  |  −  | |
|  |  | Responder | 151 (34.0) | −24.710 (2.015) |  < 0.0001 | 17.239 (2.484) | 0.0000 | |
|  | MSQ-RFR Domain | Non-responder | 309 (69.6) | −6.353 (1.352) |  < 0.0001 |  −  |  −  | |
|  |  | Responder | 135 (30.4) | −29.310 (2.045) |  < 0.0001 | 22.957 (2.452) | 0.0000 | |
|  | Monthly migraine headache days by 50% | Non-responder | 319 (71.8) | −7.616 (1.364) |  < 0.0001 |  −  |  −  | |
|  | Responder | 125 (28.2) | −27.923 (2.179) |  < 0.0001 | 20.307 (2.571) | 0.0000 | ||