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Journal of Patient-Reported Outcomes

Table 1 Demographics and clinical characteristics

From: Impact of possible tardive dyskinesia on physical wellness and social functioning: results from the real-world RE-KINECT study

 

Modified Cohort 1 (N = 450)a

Cohort 2 (N = 204)a

P-valueb

Age, mean (SD)

47.5 (14.6)

54.6 (13.6)

< 0.001

Sex, n (%)

Male

182 (40.5)

100 (49.0)

0.043

Female

267 (59.5)

104 (51.0)

Lifetime antipsychotic exposure, mean (SD), years

9.5 (9.0)

15.9 (13.9)

< 0.0001

Psychiatric condition, n (%)c

Schizophrenia or schizoaffective disorder

146 (32.4)

107 (52.5)

< 0.001

Mood or other psychiatric disorder

354 (78.7)

134 (65.7)

< 0.001

Severity of psychiatric condition, n (%)

Normal, not ill

47 (10.4)

7 (3.4)

< 0.001

Minimally ill

103 (22.9)

27 (13.2)

Mildly ill

111 (24.7)

68 (33.3)

Moderately ill

128 (28.4)

67 (32.8)

Markedly ill

43 (9.6)

26 (12.7)

Severely ill

16 (3.6)

9 (4.4)

Among the most severely ill

2 (0.4)

0

Overall health status, mean (SD)d

4.2 (2.8)

4.7 (2.8)

0.031

Overall functional status, n (%)e

Working/studying independently

242 (53.8)

66 (32.4)

< 0.001

Working/studying with assistance

100 (22.2)

44 (21.6)

Not working/studying

108 (24.0)

94 (46.1)

  1. SD standard deviation; TD tardive dyskinesia
  2. aModified Cohort 1 includes patients with no visible or self-reported abnormal involuntary movements. Cohort 2 includes all patients with possible TD per clinician assessment
  3. bFor questions or items that allowed more than 1 response (i.e., categories not mutually exclusive), P-values are provided for each response. Chi-squared tests were used for categorical variables; t-tests were used for continuous variables
  4. cBased on questionnaire responses (i.e., not diagnostic medical codes). Mood or other psychiatric disorders include bipolar disorder, major depressive disorder, anxiety disorder or symptoms, post-traumatic stress disorder, personality disorder, attention deficit hyperactivity disorder, substance use disorder, and other psychotic disorder
  5. dPer patient self-report. Higher scores indicate worse overall health (range, 0 = “no health problems” to 10 = “health as bad as you can imagine”)
  6. ePer clinician impression, based on the following options: (1) been independently working or studying full- or near full-time, in usual occupation; or managing own household; or participating in unpaid or voluntary activities, whether retired or not; (2) been working or studying with assistance in usual occupation and/or managing own household or participating in unpaid or voluntary activities; or has experienced a significant reduction in house work; or was in a sheltered situation or on sick leave; and (3) not been working or studying in any capacity and not managing own household
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