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Table 9 Sensitivity to change

From: Understanding treatment burden in hemophilia: development and validation of the Hemophilia Treatment Experience Measure (Hemo-TEM)

 

Baseline

WEEK 24

Mean difference

Effect sizea

N

Mean

SD

N

Mean

SD

Injection difficulties (3 items)

59

27.1

28.5

59

14.1

23.2

– 13.0

– 0.46

Physical impact (6 items)

59

21.6

20.7

59

15.5

19.1

– 6.1

– 0.30

Treatment bother (7 items)

59

22.3

19.0

59

10.7

14.6

– 11.7

– 0.62

Interference (4 items)

59

23.0

20.0

59

9.0

16.9

– 14.0

– 0.70

Emotional impact (6 items)

59

22.5

18.4

59

12.1

14.7

– 10.4

– 0.56

Total score

59

23.3

16.8

59

12.3

15.6

– 11.0

– 0.66

  1. aEffect size: mean change score divided by the standard deviation of the baseline score