Table 8 Meaningful within-person thresholds of ASD total scores, Item 8, and Item 9
From: Development and evaluation of the Acromegaly Symptom Diary
Change in PGI-S | n | Change in ASD total from EOT to Week 17 | |||
|---|---|---|---|---|---|
Mean ± SD | Q1, Median, Q3 | Min, Max | 95% CI | ||
1-point improvement | 2 | − 3.64 ± 5.76 | − 7.71, − 3.64, 0.43 | − 7.71, 0.43 | − 55.38 to 48.09 |
No difference | 15 | 1.12 ± 4.50 | − 1.12, 0.50, 4.21 | − 8.29, 7.86 | − 1.37 to 3.61 |
1-point worsening | 7 | 5.05 ± 5.01 | 0.14, 3.71, 9.14 | − 0.29, 12.43 | 0.42 to 9.68 |
2-point worsening | 1 | 8.57 (−) | 8.57, 8.57, 8.57 | 8.57, 8.57 | NA |
Change in sleep difficulty (Item 8) From EOT to Week 17 | |||||
3-point improvement | 0 | NA | NA | NA | NA |
2-point improvement | 0 | NA | NA | NA | NA |
1-point improvement | 2 | − 1.50 ± 1.92 | − 2.86, − 1.50, − 0.14 | − 2.86, − 0.14 | − 18.74 to 15.74 |
No difference | 15 | − 0.39 ± 1.66 | − 0.57, 0.00, 0.43 | − 5.86, 1.57 | − 1.30 to 0.53 |
1-point worsening | 7 | 0.69 ± 0.97 | 0.00, 0.00, 1.95 | 0.00, 2.14 | − 0.21 to 1.58 |
2-point worsening | 1 | 0.00 (-) | 0.00, 0.00, 0.00 | 0.00, 0.00 | NA |
3-point worsening | 0 | NA | NA | NA | NA |
Change in Short-Term Memory (Item 9) From EOT to Week 17 | |||||
3-point improvement | 0 | NA | NA | NA | NA |
2-point improvement | 0 | NA | NA | NA | NA |
1-point improvement | 1 | − 2.00 (-) | − 2.00, − 2.00, − 2.00 | − 2.00, − 2.00 | NA |
No difference | 10 | 0.19 ± 1.80 | − 0.14, 0.20, 1.23 | − 4.00, 3.00 | − 1.10 to 1.47 |
1-point worsening | 4 | − 0.01 ± 0.21 | − 0.14, 0.00, 0.12 | − 0.29, 0.24 | − 0.35 to 0.33 |
2-point worsening | 0 | NA | NA | NA | NA |
3-point worsening | 0 | NA | NA | NA | NA |