Association between VTE and antibiotic prophylaxis guideline compliance and patient-reported outcomes after total hip and knee arthroplasty: an observational study

Badge, Helen; Churches, Tim; Naylor, Justine M.; Xuan, Wei; Armstrong, Elizabeth; Gray, Leeanne; Fletcher, John; Gosbell, Iain; Christine Lin, Chung-Wei; Harris, Ian A.

doi:10.1186/s41687-022-00502-6

Journal of Patient-Reported Outcomes

Table 7 Association between clinical guideline non-compliance and EQ-5D Index score at 90 days

From: Association between VTE and antibiotic prophylaxis guideline compliance and patient-reported outcomes after total hip and knee arthroplasty: an observational study

	Beta Estimate	SE	p value
Final model for 90-day EQ-5D Index scores
Non-compliance NHMRC VTE clinical guidelines	− 0.02	0.01	0.011
Non-compliance TG Antibiotic clinical guidelines	− 0.001	0.01	0.891
EQ-5D baseline Index score	0.13	0.02	< 0.0001
EQ-5D baseline VAS score	0.001	< 0.001	< 0.0001
TKA	− 0.05	0.01	< 0.0001
Comorbid musculoskeletal condition	− 0.04	0.01	< 0.0001
Took a preoperative opioid medication for pain	− 0.04	0.01	< 0.0001
Comorbid depression or anxiety	− 0.02	0.01	0.019
ASA score 3 or 4	− 0.02	0.01	0.048
Female sex	− 0.02	0.01	0.039
Comorbid depression or anxiety	− 0.07	0.03	0.011
Surgical duration	− 0.01	0.01	0.112
First mobilised day 0 or 1	0.02	0.01	0.051
Comorbid neurological condition	− 0.04	0.02	0.055
Current smoker	− 0.03	0.01	0.043
Age	0.001	< 0.001	0.119
Comorbid liver disease	− 0.03	0.02	0.156
Comorbid current cancer	− 0.04	0.03	0.111
Final model for 365-day EQ-5D Index scores
Non-compliance NHMRC VTE clinical guidelines	− 0.03	0.01	0.002
Non-compliance TG Antibiotic clinical guidelines	− 0.01	0.01	0.383
EQ-5D Baseline Index score	0.11	0.02	< 0.0001
EQ-5D Baseline VAS score	0.001	< 0.001	0.003
Oxford baseline score	0.001	0.001	0.109
TKA	− 0.05	0.01	< 0.0001
Took a preoperative antidepressant or anticonvulsant medication for pain	− 0.07	0.03	0.015
Took a preoperative opioid medication for pain	− 0.04	0.01	< 0.0001
ASA score 3 or 4	− 0.02	0.01	0.011
Bilateral THA/TKA	0.06	0.02	0.001
Comorbid depression / anxiety	− 0.03	0.01	0.002
Comorbid lung disease	− 0.02	0.01	0.046
Comorbid musculoskeletal condition	− 0.04	0.01	< 0.0001
Other comorbid disease (not specified)	− 0.02	0.01	0.065
Comorbid sleep apnoea	− 0.04	0.02	0.004
History of stroke	− 0.03	0.02	0.084
Previous THA	− 0.03	0.01	0.020
Private hospital	0.02	0.01	0.086
Neuraxial anaesthesia	0.02	0.01	0.043
First mobilised day 0 or 1	0.02	0.01	0.012

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