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Journal of Patient-Reported Outcomes

Table 2 Demographic features and clinical diagnoses percentages by survey response status and without and with corrections for Sampling Weight and for Sampling Weight and Response Bias ‡

From: Combining patient reported outcomes and EHR data to understand population level treatment needs: correcting for selection bias in the migraine signature study

Variable

Category

Total source population1 % (SE) (N = 972,535)

Survey population from strata A-E

Survey population corrected estimates from strata A-E

Respondent1% (SE) (n = 2305)

non –respondents1 (SE) (n = 25,963)

Corrected for sampling weight % (SE) (n = 2305)

Corrected for sampling weight and response bias % (SE) (n = 2305)

Percent distribution

Sex

Female

61.5% (0.05%)

75.2% (0.9%)†,*

67.3% (0.3%)

67.0% (0.2%)††

60.0% (0.05%)

Age

18–29

10.0% (0.03%)

17.7% (0.8%)†,*

11.2% (0.2%)

19.5% (0.2%)††

10.8% (0.03%)

30–44

27.5% (0.05%)

33.6% (1.0%)†,*

28.9% (0.3%)

31.2% (0.2%)††

27.1% (0.05%)

45–64

37.8% (0.05%)

36.4% (1.0%)†,*

42.6% (0.4%)

35.1% (0.2%)††

38.0% (0.05%)

 ≥ 65

24.6% (0.04%)

12.2% (0.7%)†,*

17.4% (0.2%)

14.2% (0.1%)††

24.1% (0.04%)

Hispanic

No

76.1% (0.04%)

79.6% (0.8%)†,*

76.3% (0.3%)

79.1% (0.2%)††

76.3% (0.04%)

Yes

11.2% (0.03%)

9.7% (0.6%)†,*

11.9% (0.2%)

8.3% (0.1%)††

11.1% (0.03%)

Other

12.7% (0.03%)

10.8% (0.7%)†,*

11.7% (0.2%)

12.6% (0.1%)

12.6% (0.03%)

Race

Asian

16.8% (0.04%)

10.9% (0.6%)†,*

15.8% (0.2%)

16.0% (0.1%)

16.5% (0.04%)

Black

3.2% (0.02%)

1.9% (0.3%)†,*

3.7% (0.1%)

1.4% (0.05%)††

3.1% (0.02%)

White

54.6% (0.05%)

66.1% (1.0%)†,*

55.3% (0.3%)

62.3% (0.2%)††

54.8% (0.05%)

Other

25.4% (0.04%)

21.1% (0.8%)†,*

25.2% (0.3%)

20.3% (0.2%)††

25.6% (0.04%)

Marital status

Married/significant other

58.7% (0.05%)

54.1% (1.0%)†,*

57.4% (0.3%)

54.1% (0.2%)††

58.9% (0.05%)

Single

21.9% (0.02%)

28.7% (0.9%)†,*

25.5% (0.3%)

26.8% (0.2%)††

22.1% (0.04%)

Divorced/separated

4.5% (0.02%)

6.1% (0.5%)†,*

5.6% (0.1%)

5.5% (0.09%)††

4.6% (0.02%)

Widowed

3.9% (0.02%)

1.1% (0.2%)†,*

2.0% (0.09%)

0.9% (0.04%)††

3.8% (0.01%)

Other/unknown

11.0% (0.03%)

10.0% (0.6%)†

9.6% (0.2%)

12.6%†† (0.1%)††

10.6% (0.03%)†††

Percent of patients with a diagnosis

EHR diagnosis2

Migraine

7.7% (0.03%)

57.3% (1.0%)†,*

33.9% (0.3%)

16.7%††(0.02%)

7.7% (0.03%)

Depression

2.3% (0.02%)

3.8% (0.4%)†,*

3.2% (0.1%)

2.4% (0.06%)

2.2% (0.01%)

Anxiety

5.1% (0.02%)

8.2% (0.6%)†,*

7.4% (0.2%)

5.9%†† (0.1%)

5.1% (0.02%)

Autoimmune

1.4% (0.01%)

2.3% (0.3%)*

1.9% (0.08%)

1.5% (0.05%)

1.4% (0.01%)

Other Pain disorders

3.0% (0.02%)

4.9% (0.5%)†,*

4.0% (0.1%)

3.8%†† (0.08%)

2.9% (0.02%)

Respiratory

4.1% (0.02%)

5.8% (0.5%)†,*

5.2% (0.1%)

4.9%†† (0.09%)

4.0% (0.02%)

Cardiovascular

4.3% (0.02%)

1.8% (0.3%)†,*

3.2% (0.1%)

2.8%†† (0.07%)

4.2% (0.02%)

Neurologic

0.7% (0.01%)

1.2% (0.2)*

1.0% (0.06%)

0.8% (0.04%)

0.7% (0.01%)

Cerebrovascular

0.02% (0.005%)

0.2% (0.1%)*

0.16% (0.02%)

0.05% (0.01%)

0.01% (0.005%)

  1. ‡Covariates in the response/non-response model include: age, sex, race/ethnicity, marital status, comorbidities, acute medication orders (0, 1–2 orders, 3+ orders), preventive medication orders (0, 1–2 orders, 3+ orders)
  2. not adjusted for either sampling weight or for response bias
  3. Relevant ICD-9 codes appear 2+ times in a 1-year period as an encounter diagnosis or a medication order indication
  4. †Statistically significant comparing respondents versus non-respondents
  5. *Statistically significant comparing respondents versus source population
  6. ††Statistically significant comparing adjusted for sample weight estimate versus source population
  7. †††Statistically significant comparing full adjustment estimate versus source population
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