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Table 3 Health-related quality of life (HRQOL) scores by mode of administration

From: Score equivalence of paper-, tablet-, and interactive voice response system-based versions of PROMIS, PRO-CTCAE, and numerical rating scales among cancer patients

Domain questionnaire and scale PSAQ mean (SD) CSAQ mean (SD) IVR mean (SD)
Global/general health    
PROMIS global mental 48.6 (8.2) 49.6 (8.5) 50.4 (7.9)
PROMIS global physical 43.7 (8.3) 44.0 (8.5) 44.1 (7.6)
NRS overall QOL 72.6 (20.7) 74.4 (20.2) 72.2 (21.5)
NRS emotional well-being 75.7 (21.0) 77.1 (19.4) 75.3 (20.4)
NRS mental well-being 80.2 (19.6) 81.1 (18.4) 78.8 (19.7)
Physical function    
PROMIS physical function 43.7 (8.3) 44.0 (8.5) 44.1 (7.6)
NRS physical well-being 69.6 (22.4) 71.2 (20.2) 71.9 (21.6)
Social function    
PROMIS social function 48.5 (9.6) 49.0 (9.6) 49.2 (8.8)
NRS social activity 66.0 (26.0) 68.5 (24.1) 69.6 (23.9)
Emotional distress—anxiety    
PROMIS anxiety 50.2 (9.8) 49.3 (9.6) 49.2 (9.2)
NRS anxiety 28.2 (26.6) 27.6 (27.3) 22.7 (24.1)
PRO-CTCAE anxiety frequency 32.2 (25.9) 29.3 (25.1) 25.0 (24.6)
PRO-CTCAE anxiety severity 27.7 (24.1) 25.0 (23.1) 22.0 (22.2)
PRO-CTCAE anxiety interference 16.9 (23.2) 15.3 (22.9) 12.2 (19.8)
Emotional distress—depression    
PROMIS depression 48.0 (9.1) 47.4 (8.9) 48.1 (7.8)
NRS depression 17.4 (23.1) 16.7 (23.2) 12.7 (18.7)
PRO-CTCAE cheer frequency 16.4 (22.5) 15.7 (22.8) 12.7 (19.5)
PRO-CTCAE cheer severity 14.3 (22.0) 13.0 (20.8) 10.4 (17.4)
PRO-CTCAE cheer interference 12.4 (20.9) 10.7 (20.1) 9.0 (17.1)
PRO-CTCAE sad frequency 29.4 (23.8) 27.7 (24.0) 24.3 (20.4)
PRO-CTCAE sad severity 24.1 (21.7) 23.3 (22.2) 20.0 (19.7)
PRO-CTCAE sad interference 14.8 (21.8) 13.6 (21.7) 11.4 (18.6)
Fatigue    
PROMIS fatigue 53.0 (9.0) 52.2 (9.4) 51.0 (8.7)
NRS fatigue 40.7 (26.0) 39.5 (27.1) 33.9 (24.6)
PRO-CTCAE fatigue severity 41.2 (23.8) 39.8 (24.5) 36.5 (23.4)
PRO-CTCAE fatigue interference 36.7 (26.8) 36.3 (27.7) 31.8 (24.8)
Sleep    
PROMIS sleep disturbance 50.1 (9.6) 49.2 (9.3) 49.6 (8.9)
NRS sleep overall 36.5 (25.2) 33.7 (23.5) 34.4 (23.4)
PRO-CTCAE sleep severity 33.9 (26.9) 30.2 (25.8) 28.1 (25.9)
PRO-CTCAE sleep interference 25.5 (26.1) 25.1 (26.3) 21.1 (24.1)
Pain    
PROMIS pain intensity 49.7 (10.6) 49.5 (11.0) 48.4 (10.8)
PROMIS pain interference 51.8 (9.9) 51.3 (10.0) 50.7 (9.5)
NRS pain frequency 29.3 (29.4) 27.8 (28.7) 26.0 (28.7)
NRS pain severity 25.9 (26.2) 25.9 (27.1) 23.7 (25.5)
PRO-CTCAE pain frequency 38.0 (30.6) 38.6 (32.0) 35.1 (31.8)
PRO-CTCAE pain severity 32.0 (26.8) 32.1 (27.9) 30.2 (28.4)
PRO-CTCAE pain interference 24.5 (27.9) 24.7 (28.7) 22.1 (26.8)
  1. PSAQ means paper-and-pencil self-administered questionnaire, CSAQ computerized self-administered questionnaire, and IVR questionnaire completed using interactive voice recording. The PROMIS scores were on a T-score metric, whereas NRS and PRO-CTCAE items were transformed to 0–100 scale