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Table 6 Estimates of important difference on EPP-Symptoms scale based on benchmark criteria from DLQI and 60 day peak phototoxicity severity

From: Validation of a novel patient reported tool to assess the impact of treatment in erythropoietic protoporphyria: the EPP-QoL

EPP-Symptoms

Benchmark difference

Difference estimate

DLQI criteria

Moderate – Very large effect

26.5

Very large – Extremely large effect

9.8

60 day peak phototoxicity severity

None – mild

5.5

Mild –Moderate

19.1

Moderate – Severe

14.9

Severe – Worst imaginable

3.1