Table 9 Observational study known-groups validity hypotheses for HPES-Impact

Total

PGIS-Overall

Patients with higher levels of severity on PGIS-Overall will have a higher mean score than patients with less severity

1 = No noticeable symptoms/Very mild

18

7.8 (3.25)

Overall < 0.0001

1 vs. 2 0.0007

1 vs. 3 < 0.0001

1 vs. 4 < 0.0001

2 vs. 3 < 0.0001

2 vs. 4 < 0.0001

3 vs. 4 < 0.0001

Yes

2 = Mild

92

21.6 (1.44)

3 = Moderate

160

38.3 (1.09)

4 = Severe/Very severe

30

56.1 (2.52)

PGIS-Physical

Patients with higher levels of severity on the PGIS-Physical will have a higher mean score than patients with less severity

1 = No noticeable symptoms/Very mild

20

7.1 (3.20)

Overall < 0.0001

1 vs. 2 < 0.0001

1 vs. 3 < 0.0001

1 vs. 4 < 0.0001

2 vs. 3 < 0.0001

2 vs. 4 < 0.0001

3 vs. 4 < 0.0001

Yes

2 = Mild

99

24.3 (1.44)

3 = Moderate

140

37.4 (1.21)

4 = Severe/Very severe

41

52.8 (2.24)

PGIS Cognitive

Patients with higher levels of severity on the PGIS Cognitive will have a higher mean score than patients with less severity

1 = No noticeable symptoms/Very mild

33

13.4 (2.72)

Overall < 0.0001

1 vs. 2 < 0.0001

1 vs. 3 < 0.0001

1 vs. 4 < 0.0001

2 vs. 3 < 0.0001

2 vs. 4 < 0.0001

3 vs. 4 0.0098

Yes

2 = Mild

113

28.1 (1.47)

3 = Moderate

107

38.4 (1.51)

4 = Severe/Very severe

47

47.1 (2.28)

Physical Functioning

Physically active (Question 18)

Patients who report being less physically active will have a higher mean score than patients who are more physically active

1 = Not at all

9

57.8 (6.61)

Overall < 0.0001

1 vs. 2 0.0776

1 vs. 3 0.0018

1 vs. 4 < 0.0001

2 vs. 3 0.0457

2 vs. 4 < 0.0001

3 vs. 4 0.0311

Yes

2 = A little

73

40.3 (2.32)

3 = Some

174

32.9 (1.50)

4 = A lot/Extremely

44

23.5 (2.99)

Daily Life

Energy (Question 19)

Patients with lower energy (greater impact) levels during the day will have a higher mean score than patients with higher energy levels

1 = Not at all

13

69.6 (5.07)

Overall < 0.0001

1 vs. 2 < 0.0001

1 vs. 3 < 0.0001

1 vs. 4 < 0.0001

2 vs. 3 0.0062

2 vs. 4 < 0.0001

3 vs. 4 0.1217

Yes

2 = A little

136

37.8 (1.57)

3 = Some

121

30.2 (1.66)

4 = A lot/Extremely

30

21.6 (3.34)

Employment status

Patients who report being currently employed will have a higher mean score than patients who are unemployed

1 = Yes

250

30.9 (1.18)

Overall < 0.0001

1 vs. 2 < 0.0001

No; but the hypothesis was flawed. The results are logical (less impact may lead to being able to work)

2 = No

50

52.3 (2.65)

Social Life and Relationships

Friends and Family (Question 20)

Patients who report less family support will have a higher mean score than patients with more family support

1 = Not at all

12

48.3 (6.06)

Overall 0.0022

1 vs. 2 0.2912

1 vs. 3 0.1162

1 vs. 4 0.0109

1 vs. 5 0.0050

2 vs. 3 0.9996

2 vs. 4 0.2999

2 vs. 5 0.1418

3 vs. 4 0.4792

3 vs. 5 0.2350

4 vs. 5 0.9982

Yes

2 = A little

70

34.4 (2.51)

3 = Some

155

32.5 (1.69)

4 = A lot

42

25.7 (3.24)

5 = Extremely

21

21.6 (4.58)

Psychological Well-Being

Number of comorbid issues (Question 15)

Patients who report a higher number of comorbidity issues will have a higher mean score than patients with fewer comorbidity issues

1 = 25th percentile or less

174

31.7 (1.42)

1 vs. 2 0.0026

Yes

2 = 75th percentile or more

81

39.4 (2.08)