Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES)

Journal of Patient-Reported Outcomes

Table 3 Observational study construct validity hypotheses for HPES-Symptom at baseline

HPES-Symptom scale	Supporting measure	Construct validity hypothesis	Correlation values
Total	▪ PGIS-Overall	Moderate to strong correlations with PGIS-Overall scores (to support convergent validity)	0.59
Total	▪ MFI	Moderate to strong correlations with MFI scores	General Fatigue = 0.63 Physical Fatigue = 0.47 Reduced Motivation = 0.49 Reduced Activity = 0.42 Mental Fatigue = 0.55
Physical	▪ PGIS-Physical ▪ PGIS Cognitive	Moderate to strong correlations with PGIS-Physical scores (to support convergent validity) and less strong correlations with PGIS Cognitive scores (to support divergent validity)	PGIS-Physical = 0.55 PGIS Cognitive = 0.39
Physical	▪ DSQ2-PEM ▪ DSQ2-Sleep disturbances	Moderate to strong correlations with PEM and Sleep-DSQ2 scores	0.72 0.69
Cognitive	▪ PGIS Cognitive ▪ PGIS-Physical	Moderate to strong correlations with PGIS Cognitive scores (to support convergent validity) and less strong correlations with PGIS-Physical scores (to support divergent validity)	PGIS Cognitive = 0.50 PGIS-Physical = 0.43
Cognitive	▪ CFQ	Moderate to strong correlations with CFQ scores	0.59

CFQ Cognitive Failures Questionnaire, DSQ-2 DePaul Symptoms Questionnaire – Version 2, HPES Hypoparathyroidism Patient Experience Scale, MFI Multidimensional Fatigue Inventory, PEM Post-Exertional Malaise domain (of the DSQ-2), PGIS patient global impression of severity