Testing the validity and responsiveness of a new cancer-specific health utility measure (FACT-8D) in relapsed/refractory mantle cell lymphoma, and comparison to EQ-5D-5L

Journal of Patient-Reported Outcomes

Table 2 Known groups’ validity for FACT-8D and EQ-5D-5L Index scores, using baseline data

	FACT-8D		EQ-5D-5L crosswalk		EQ-5D-5L EVS
	Mean (SD)	P value	Mean (SD)	P value	Mean (SD)	P value
Baseline lymphoma symptoms		0.02		< .0001		< .0001
No (N = 117)	0.69 (0.18)		0.81 (0.21)		0.87 (0.16)
Yes (N = 133)	0.63 (0.28)		0.67 (0.22)		0.75 (0.21)
Presence lymphoma B symptoms^a		< 0.01		< 0.001		< 0.001
No symptoms (N = 186)	0.68 (0.20)		0.77 (0.20)		0.84 (0.16)
One or more symptoms present (N = 64)	0.60 (0.32)		0.63 (0.28)		0.71 (0.26)
Other MCL-related symptoms		0.10		<.0001		< .0001
No (N = 140)	0.67 (0.22)		0.79 (0.21)		0.85 (0.17)
Yes (N = 110)	0.63 (0.27)		0.66 (0.24)		0.74 (0.22)
ECOG^b		< .0001		< .0001		< .0001
0 (N = 117)	0.74 (0.22)		0.82 (0.18)		0.88 (0.15)
1(N = 130)	0.58 (0.25)		0.66 (0.23)		0.74 (0.21)
MIPI		0.21		< 0.001		0.001
High Risk (N = 53)	0.61 (0.27)		0.63 (0.28)		0.72 (0.26)
Intermediate (N = 118)	0.66 (0.24)		0.75 (0.18)		0.82 (0.16)
Low Risk (N = 79)	0.68 (0.23)		0.78 (0.23)		0.84 (0.19)
HgB		0.14		< 0.001		< 0.001
HGB < 130 g/L (N = 137)	0.60 (0.27)		0.69 (0.24)		0.77 (0.22)
HGB > =130 g/L (N = 113)	0.64 (0.20)		0.79 (0.19)		0.85 (0.16)
Previous lines of therapy		0.43		0.35		0.35
1 (N = 98)	0.68 (0.24)		0.74 (0.23)		0.81 (0.19)
2 (N = 69)	0.64 (0.24)		0.75 (0.23)		0.82 (0.18)
≥3 (N = 83)	0.64 (0.25)		0.70 (0.23)		0.78 (0.22)

ECOG Eastern Cooperative Oncology Group, EVS England value set, MCL Mantle cell lymphoma, MIPI Mantle Cell Lymphoma International Prognostic Index, HgB haemoglobin
^aLymphoma B symptoms are symptoms common in lymphomas affecting B-cells and include, among others, fever, night sweats, persistent fatigue, or itchy skin. ^bPatients in ECOG performance status 0 are patients considered to be fully active with no performance restriction. Patients in ECOG performance status 1 are those who are restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature