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Table 2 Known groups’ validity for FACT-8D and EQ-5D-5L Index scores, using baseline data

From: Testing the validity and responsiveness of a new cancer-specific health utility measure (FACT-8D) in relapsed/refractory mantle cell lymphoma, and comparison to EQ-5D-5L

 FACT-8DEQ-5D-5L crosswalkEQ-5D-5L EVS
Mean (SD)P valueMean (SD)P valueMean (SD)P value
Baseline lymphoma symptoms 0.02 < .0001 < .0001
 No (N = 117)0.69 (0.18) 0.81 (0.21) 0.87 (0.16) 
 Yes (N = 133)0.63 (0.28) 0.67 (0.22) 0.75 (0.21) 
Presence lymphoma B symptomsa < 0.01 < 0.001 < 0.001
 No symptoms (N = 186)0.68 (0.20) 0.77 (0.20) 0.84 (0.16) 
 One or more symptoms present (N = 64)0.60 (0.32) 0.63 (0.28) 0.71 (0.26) 
Other MCL-related symptoms 0.10 <.0001 < .0001
 No (N = 140)0.67 (0.22) 0.79 (0.21) 0.85 (0.17) 
 Yes (N = 110)0.63 (0.27) 0.66 (0.24) 0.74 (0.22) 
ECOGb < .0001 < .0001 < .0001
 0 (N = 117)0.74 (0.22) 0.82 (0.18) 0.88 (0.15) 
 1(N = 130)0.58 (0.25) 0.66 (0.23) 0.74 (0.21) 
MIPI 0.21 < 0.001 0.001
 High Risk (N = 53)0.61 (0.27) 0.63 (0.28) 0.72 (0.26) 
 Intermediate (N = 118)0.66 (0.24) 0.75 (0.18) 0.82 (0.16) 
 Low Risk (N = 79)0.68 (0.23) 0.78 (0.23) 0.84 (0.19) 
HgB 0.14 < 0.001 < 0.001
 HGB < 130 g/L (N = 137)0.60 (0.27) 0.69 (0.24) 0.77 (0.22) 
 HGB > =130 g/L (N = 113)0.64 (0.20) 0.79 (0.19) 0.85 (0.16) 
Previous lines of therapy 0.43 0.35 0.35
 1 (N = 98)0.68 (0.24) 0.74 (0.23) 0.81 (0.19) 
 2 (N = 69)0.64 (0.24) 0.75 (0.23) 0.82 (0.18) 
 ≥3 (N = 83)0.64 (0.25) 0.70 (0.23) 0.78 (0.22) 
  1. ECOG Eastern Cooperative Oncology Group, EVS England value set, MCL Mantle cell lymphoma, MIPI Mantle Cell Lymphoma International Prognostic Index, HgB haemoglobin
  2. aLymphoma B symptoms are symptoms common in lymphomas affecting B-cells and include, among others, fever, night sweats, persistent fatigue, or itchy skin. bPatients in ECOG performance status 0 are patients considered to be fully active with no performance restriction. Patients in ECOG performance status 1 are those who are restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature