The Treatment-induced Neuropathy Assessment Scale (TNAS): a psychometric update following qualitative enrichment

Mendoza, Tito R.; Williams, Loretta A.; Shi, Qiuling; Wang, Xin Shelley; Bamidele, Oluwatosin; Woodruff, Jeanie F.; Cleeland, Charles S.

doi:10.1186/s41687-020-0180-8

Journal of Patient-Reported Outcomes

Table 1 The development of the TNAS and the accompanying changes

From: The Treatment-induced Neuropathy Assessment Scale (TNAS): a psychometric update following qualitative enrichment

TNAS version	Number of items	Methods	Changes made	Next steps
1	11	Expert clinician input, literature review	Original TNAS	Cognitive debriefing and psychometric analysis
2^a	13	Cognitive debriefing, psychometric analysis	Two items were added: • “Feeling of coldness in hands/feet/fingers at its WORST” • “Swelling in hands and feet at its WORST”	In-depth qualitative interviewing, literature review
3^b	10	In-depth qualitative interviewing, literature review	Five items were removed: • “Sensations of pin/needles in arms/legs at their WORST” • “Sensations of electric shock at their WORST” • “Cramps in your hands/feet at their WORST” • “Discomfort when touching things at its WORST” •“Discomfort when your skin comes in contact with something at its WORST” One item was split into two: • “Numbness or tingling in your hands or feet at its WORST” became ◦ “Numbness in your arms, legs, hands or feet at its WORST” ◦ “Tingling in your arms, legs, hands or feet at its WORST” Two items were added: • “Trouble finding or wearing shoes at its WORST” • “Disturbed sleep at its WORST” Six items were modified: • “Pain when touching cold things at its WORST” became “Pain in your arms, legs, hands, or feet at its WORST” • “Hot or burning sensation in hands or feet at their WORST” became “Hot or burning sensations in your arms, legs, hands, or feet at their WORST” • “Feelings of coldness in hands, feet, or fingers at its WORST” became “Feelings of coldness in your hands or feet at its WORST” • “Trouble grasping small objects at its WORST” became “Difficulty using your hands or fingers at its WORST” • “Trouble walking due to loss of feeling in your legs or feet at its WORST” became “Trouble walking at its WORST” • “Difficulty with your balance due to loss of feeling in your legs or feet at its WORST” became “Trouble with your balance or falling at its WORST”	Cognitive debriefing and psychometric analysis
3	9	Cognitive debriefing and psychometric analysis	One item was removed: •“Trouble finding or wearing shoes at its WORST”	Cognitive debriefing and psychometric analysis

Abbreviation: TNAS Treatment-induced Neuropathy Assessment Scale
^aFurther details are described in Mendoza et al., 2015 [8]
^bFurther details are described in Williams et al., 2018 [11]

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