Table 2 Consolidated symptom conceptualization of patient experience with MDS, AML and CMML
Disease- and Treatment-Related Symptoms of Higher-Risk MDS, Low-Blast Count AML, and CMML | |||
|---|---|---|---|
PT | LIT | CLINa | |
Gastrointestinal | |||
Nausea | ✓ | ✓ | ✓ |
Constipation | ✓ | ✓ | ✓ |
Vomiting | ✓ | ✓ | |
Diarrhea | ✓ | ✓ | |
Distension | ✓ | ||
Feeling full after eating little food | ✓ | ||
Bloating | ✓ | ||
Loss of appetite | ✓ | ||
Fatigue | |||
Weakness | ✓ | ✓ | ✓ |
Easily fatigued | ✓ | ✓ | ✓ |
Tiredness | ✓ | ✓ | ✓ |
Low Energy | ✓ | ✓ | ✓ |
Exhausted | ✓ | ||
Heaviness (arms/legs) | ✓ | ✓ | |
Sluggish | ✓ | ✓ | ✓ |
Worn out | ✓ | ✓ | |
Pain | |||
Bone pain | ✓ | ✓ | |
Muscle pain/soreness | ✓ | ✓ | ✓ |
Headache | ✓ | ✓ | ✓ |
Cramps | ✓ | ||
Chemical burn | ✓ | ||
Bleeding | |||
Bleeding | ✓ | ✓ | ✓ |
Bruising | ✓ | ✓ | |
Petechiae | ✓ | ||
Cognitive function | |||
Difficulty concentrating | ✓ | ✓ | ✓ |
Memory loss | ✓ | ||
Confusion | ✓ | ||
Sensory | |||
Dry throat/mouth | ✓ | ✓ | |
Tastelessness | ✓ | ||
Taste changes | ✓ | ||
Dry lips | ✓ | ||
Ringing in the ears | ✓ | ||
Numbness | ✓ | ✓ | |
Cold hands/feet | ✓ | ||
Feeling cold | ✓ | ||
Itchy skin | ✓ | ||
Other | |||
Shortness of breath | ✓ | ✓ | ✓ |
Rash | ✓ | ✓ | |
Infection (e.g., cough, chest congestion, sputum production, dysuria) | ✓ | ✓ | |
Dizziness | ✓ | ✓ | |
Lightheaded | ✓ | ||
Dyspnea on exertion | ✓ | ✓ | ✓ |
High fever/chills | ✓ | ✓ | ✓ |
Paleness | ✓ | ✓ | |
Weight gain/loss | ✓ | ✓ | |
Hair loss | ✓ | ✓ | |
Vertigo | ✓ | ✓ | |
Anorexia | ✓ | ✓ | |
Cardiac issues | ✓ | ✓ | |
Eyes tearing | ✓ | ||
Skin peeling | ✓ | ||
Skin tearing | ✓ | ||
Swelling (lymph nodes) | ✓ | ||
Dysphagia (difficulty swallowing) | ✓ | ||