Table 3 Disutility estimates of parental spillover quantifying health-related quality of life losses due to childhood conditions
From: Health utilities and parental quality of life effects for three rare conditions tested in newborns
N | Disutility | Spillover decrement relative to child disutility | |||
|---|---|---|---|---|---|
Mean | 95% CIa | Percent | 95% CI | ||
Krabbe Disease | |||||
Early Stage Illness, 6 months | 167 | 0.152 | 0.110–0.195 | 32.4 | 26.9–36.7 |
Advanced Stage Illness, 6 months | 167 | 0.190 | 0.141–0.238 | 50.8 | 44.6–55.3 |
Early Stage Illness, 8 years | 168 | 0.136 | 0.096–0.177 | 24.8 | 19.6–29.2 |
Advanced Stage Illness, 8 yr | 168 | 0.163 | 0.119–0.208 | 37.0 | 31.3–41.6 |
Phenylketonuria | |||||
Less Adherent to Diet, 8 yr | 170 | 0.120 | 0.079–0.160 | 21.3 | 15.6–25.7 |
More Adherent to Diet, 8 yr | 171 | 0.110 | 0.072–0.148 | 17.2 | 12.4–21.3 |
Pompe Disease | |||||
Severe Symptoms, 6 months | 170 | 0.180 | 0.129–0.230 | 45.1 | 37.8–50.3 |
Mild Symptoms, 8 yr | 171 | 0.072 | 0.042–0.103 | 9.0 | 5.6–12.2 |
Moderate Symptoms, 8 yr | 169 | 0.162 | 0.116–0.208 | 39.1 | 32.7–43.8 |
Severe Symptoms, 8 yr | 171 | 0.131 | 0.090–0.173 | 28.1 | 22.1–33.0 |
ERT Treatment, 8 yr | 169 | 0.155 | 0.110–0.200 | 32.6 | 26.4–37.5 |