Development and adaptation of patient-reported outcome measures for patients who experience itch associated with primary biliary cholangitis

Journal of Patient-Reported Outcomes

Table 4 Summary of impact concept code frequency totals by subdomain

PBC Impact Subdomains and Concepts	Total Participant Symptom Expressions Within Concept, n (%) N = 571	Transcripts Contributing to Concept Expressions, n (%) N = 20
Changes in daily performance	119 (21)	18 (90)
Emotional functioning	103 (18)	19 (95)
Sleep difficulties caused by itching or other symptoms	98 (17)	18 (90)
Limitations to relationships and social functioning	87 (15)	16 (80)
Limitations to lifestyle and activities	84 (15)	20 (100)
Additional impacts^a	80 (14)	19 (95)

PBC, primary biliary cholangitis
^aDecreased quality of life, economic burden, scratching until skin is raw or infected, treatment burden, physical discomfort, and weight gain