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Table 2 Summary of symptom concept code frequency totals by subdomain

From: Development and adaptation of patient-reported outcome measures for patients who experience itch associated with primary biliary cholangitis

PBC Symptom Subdomains and Concepts Total Language Expressions Within Concept, n (%)
N = 642
Transcripts Contributing to Concept Expressions, n (%)
N = 20
Itching-related signs and symptoms 293 (46) 20 (100)
 Itching 254 (39.6) 20 (100)
 Hives 12 (1.9) 3 (15)
 Burning 9 (1.4) 3 (15)
 Rash 9 (1.4) 3 (15)
 Tingling 8 (1.2) 4 (20)
 Dry patches 1 (0.2) 1 (5)
Energy-related signs and symptoms 87 (14) 18 (90)
 Fatigue 44 (6.9) 17 (85)
 Tiredness 16 (2.5) 9 (45)
 Low energy 14 (2.2) 6 (30)
 Exhaustion 8 (1.2) 7 (35)
 Weakness 5 (0.8) 4 (20)
Additional signs and symptoms 86 (13) 19 (95)
 Other symptomsa 20 (3.1) 11 (55)
 Dry eyes 13 (2.0) 10 (50)
 Gallstones 9 (1.4) 8 (40)
 Dry mouth 8 (1.2) 8 (40)
 Weak/brittle bones 8 (1.2) 5 (25)
 Fat deposits on skin 8 (1.2) 6 (30)
 Darkening of skin 8 (1.2) 6 (30)
 Hair loss 3 (0.5) 2 (10)
 Jaundice 3 (0.5) 2 (10)
 Sleep disturbance 3 (0.5) 3 (15)
 Swelling 3 (0.5) 3 (15)
Pain and discomfort 77 (12) 19 (95)
 Joint pain/aches 23 (3.6) 10 (50)
 Discomfort in right side 21 (3.3) 11 (55)
 Muscle pain/aches 9 (1.4) 5 (25)
 General pain 8 (1.2) 6 (30)
 Other pain and discomfort 8 (1.2) 8 (40)
 Abdominal pain 4 (0.6) 4 (20)
 Bone pain/aches 4 (0.6) 3 (15)
GI signs and symptoms 69 (11) 16 (80)
 Diarrhea 17 (2.6) 10 (50)
 Nausea 12 (1.9) 7 (35)
 Abdominal bloating 11 (1.7) 10 (50)
 Other GI symptoms 10 (1.6) 7 (35)
 Urgency with bowel movements 7 (1.1) 7 (35)
 Greasy diarrhea 6 (0.9) 5 (25)
 Indigestion/heartburn 3 (0.5) 3 (15)
 Changes in appetite 3 (0.5) 3 (15)
Cognitive signs and symptoms 30 (5) 10 (50)
 Difficulty concentrating 11 (1.7) 7 (35)
 Difficulty remembering things 9 (1.4) 7 (35)
 Other cognitive symptoms 4 (0.6) 2 (10)
 Brain fog 3 (0.5) 2 (10)
 Confusion 3 (0.5) 2 (10)
  1. GI, gastrointestinal; PBC, primary biliary cholangitis
  2. aOther symptoms include: bruises easily, cellulitis, changes in taste, chest infections, eye problems, fibromatosis, flushed, fluid in abdomen, heat intolerance, kidney stones, no hair growth, redness, restless legs, shingles, shortness of breath, and sweating