Impact of possible tardive dyskinesia on physical wellness and social functioning: results from the real-world RE-KINECT study

Journal of Patient-Reported Outcomes

Table 3 EQ-5D-5L and SDS scores by clinician and patient ratings of severity or impact

Severity or impact of possible TD	Cohort 2 or 2A^ab versus modified Cohort 1^c
Severity or impact of possible TD	EQ-5D-5L utility score (SE)^d	SDS total score (SE)^d
Cohort 2^a
“Some” or “a lot” of clinician-rated severity (n = 204)	− 0.037 (0.015)*	0.267 (0.756)
“A lot” of clinician-rated severity (n = 68)	− 0.044 (0.023)	− 0.732 (1.139)
Cohort 2A^b
“Some” or “a lot” of patient-rated severity (n = 110)	− 0.036 (0.019)	1.428 (0.931)
“A lot” of patient-rated severity (n = 52)	− 0.089 (0.024)***	3.288 (1.243)**
“Some” or “a lot” of patient-rated impact (n = 83)	− 0.042 (0.021)*	1.675 (1.053)
“A lot” of patient-rated impact (n = 33)	− 0.121 (0.031)***	5.401 (1.509)***

EQ-5D-5L EuroQoL 5-dimension 5-level questionnaire; SDS Sheehan Disability Scale; SE standard error; TD tardive dyskinesia
*P < 0.05; **P < 0.01; ***P < 0.001 (significantly worse for Cohort 2 subgroup versus modified Cohort 1). Adjusted for age, sex, overall health status, severity of psychiatric condition per clinician impression, functional status of patient per clinician impression, and psychiatric diagnosis
^aCohort 2 included all patients with possible TD per clinician assessment. By definition, all Cohort 2 patients had a clinician-rated severity of “some” or “a lot” in ≥ 1 body region (N = 204)
^bCohort 2A included patients who were aware of their possible TD. By definition, all Cohort 2A patients rated their severity as “some” or “a lot” in ≥ 1 body region (N = 110). Not all aware patients reported having “some” or “a lot” of impact on daily activities; 27 aware patients either reported “none” for all 7 activities or did not provide a response
^cModified Cohort 1 included patients who had no abnormal involuntary movements (N = 450)
^dBased on linear regression analyses of mean score differences between Cohort 2 subgroups and modified Cohort 1. Negative values for EQ-5D-5L utility score indicate worse health-related quality of life for Cohort 2 populations. Positive values for SDS total scores indicate worse functioning for Cohort 2 populations