Table 2 Anchor-based change from baseline to Week 52 for individual VAS scores

Mean (95% CIs)

Overall VAS score*

Minimal improvement n = 49

− 3.16 (− 3.42, − 2.90)

− 1.11 (− 1.58, − 0.65)

–

− 3.25 (− 3.65, − 2.86)

− 3.25 (− 3.77, − 2.73)

− 2.99 (− 3.46, − 2.52)

Stable n = 85

− 0.45 (− 0.63, − 0.26)

− 0.33 (− 0.50, − 0.16)

− 0.55 (− 0.87, − 0.23)

− 0.54 (− 0.91, − 0.16)

− 0.49 (− 0.88, − 0.11)

SNOT-22 total score^†

Minimal improvement, n = 31

− 2.80 (− 3.70, − 1.90)

− 1.51 (− 2.46, − 0.57)

− 2.94 (− 3.92, − 1.97)

− 2.58 (− 3.51, − 1.65)

− 2.33 (− 3.37, − 1.29)

− 2.62 (− 3.64, − 1.59)

Stable, n = 38

− 1.77 (− 2.61, − 0.93)

− 1.05 (− 1.83, − 0.27)

− 1.84 (− 2.69, − 0.99)

− 1.80 (− 2.64, − 0.96)

− 2.07 (− 2.94, − 1.20)

− 1.58 (− 2.50, − 0.66)

SNOT-22 nasal obstruction^‡

Minimal improvement, n = 86

− 4.66, (− 5.23, − 4.09)

–

–

–

–

–

Stable, n = 113

− 2.62 (− 3.12, − 2.13)

SNOT-22 loss of taste or smell^‡

Minimal improvement, n = 43

− 

− 4.35 (− 5.24, − 3.46)

–

–

–

–

Stable, n = 187

− 1.05 (− 1.34, − 0.75)

SNOT-22 thick nasal discharge^‡

Minimal improvement, n = 81

–

–

–

− 5.08 (− 5.76, − 4.39)

–

–

Stable, n = 113

− 2.75 (− 3.27, − 2.23)

SNOT-22 post-nasal discharge^‡

Minimal improvement, n = 75

–

–

–

–

− 4.83 (− 5.49, − 4.17)

–

Stable, n = 137

− 2.96 (− 3.47, − 2.44)

SNOT-22 facial pain/pressure^‡

Minimal improvement, n = 78

–

–

–

–

–

− 4.82 (− 5.51, − 4.14)

Stable, n = 130

− 2.66 (− 3.18, − 2.13)