Development and evaluation of the Acromegaly Symptom Diary

Journal of Patient-Reported Outcomes

Table 7 Responsiveness correlations of the ASD weekly total scores

Change/supporting measure	Correlation with change in ASD Total
Change from screening visit to baseline (n = 29)
PGI-S	0.19
IGF-I (× ULN)	− 0.03
Growth hormone (ng/mL)	0.06
Change from EOT to Week 17 (n = 24 to 25)
PGI-S	0.53*
IGF-I (× ULN)	0.52*
Growth hormone (ng/mL)	0.56*
AcroQoL total score	− 0.08
EQ-5D-5 L pain/discomfort	− 0.06
EQ-5D-5 L mobility	− 0.11
EQ-5D-5 L self-care	− 0.01
EQ-5D-5 L usual activities	− 0.12
EQ-5D-5 L anxiety/depression	− 0.21
EQ-VAS	− 0.08

*P < 0.05 test for H0: ρ = 0
ASD = Acromegaly Symptom Diary; EOT = end of treatment; EQ-VAS = EQ visual analogue scale; IGF-I = insulin-like growth factor I; ULN = upper limit of normal; PGI-S = Patient Global Impression of Severity