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Table 2 PMMSA weekly scores (mean [SD])

From: Psychometric performance of the Primary Mitochondrial Myopathy Symptom Assessment (PMMSA) in a randomized, double-blind, placebo-controlled crossover study in subjects with mitochondrial disease

Item

Baseline

Week 4

Treatment 1 end

Week 6

Nurse home visit

Week 8

Washout end

Week 12 Treatment 2 end

Week 14

Two weeks post-treatment 2

(N = 30)

(N = 29)

(N = 29)

(N = 30)

(N = 28)

(N = 28)

Tiredness at rest

2.82 (0.66)

2.55 (0.70)

2.69 (0.62)

2.73 (0.65)

2.45 (0.74)

2.63 (0.72)

Tiredness during activities

3.06 (0.63)

2.61 (0.70)

2.94 (0.63)

2.89 (0.73)

2.63 (0.78)

2.77 (0.70)

Muscle weakness at rest

2.49 (0.71)

2.29 (0.77)

2.51 (0.75)

2.54 (0.69)

2.28 (0.68)

2.49 (0.74)

Muscle weakness during activities

2.93 (0.71)

2.54 (0.74)

2.86 (0.73)

2.87 (0.75)

2.63 (0.77)

2.79 (0.65)

Balance problems

2.53 (0.78)

2.44 (0.82)

2.51 (0.80)

2.46 (0.77)

2.38 (0.77)

2.56 (0.76)

Vision problems

2.04 (1.01)

2.06 (0.97)

2.22 (0.99)

2.29 (1.00)

2.17 (0.95)

2.26 (1.02)

Abdominal discomfort

1.82 (0.79)

1.82 (0.67)

1.94 (0.70)

1.90 (0.78)

1.85 (0.78)

1.94 (0.89)

Muscle pain

2.33 (0.94)

2.20 (0.86)

2.34 (0.85)

2.40 (0.94)

2.27 (0.88)

2.47 (0.89)

Numbness

1.70 (0.86)

1.79 (0.92)

1.67 (0.82)

1.84 (0.93)

1.73 (0.74)

1.91 (0.86)

Headache

1.61 (0.70)

1.43 (0.52)

1.67 (0.67)

1.65 (0.71)

1.49 (0.54)

1.71 (0.74)

TSS

23.33 (5.12)

21.74 (5.08)

23.35 (4.63)

23.56 (5.23)

21.88 (5.02)

23.53 (5.29)

4FS

11.30 (2.50)

10.00 (2.77)

11.00 (2.55)

11.02 (2.63)

9.99 (2.84)

10.68 (2.68)

2FS

5.99 (1.30)

5.15 (1.41)

5.80 (1.31)

5.76 (1.45)

5.26 (1.52)

5.56 (1.32)

  1. PMMSA 10-item weekly scores have a possible range of 10 to 40. PMMSA Fatigue 4 weekly scores have a possible range of 4 to 16. PMMSA 2-item weekly scores have a possible range of 2 to 8. Individual item weekly averages may range from 1 to 4
  2. 2FS = two-item fatigue score; 4FS = Fatigue 4 Scale; PMMSA = Primary Mitochondrial Myopathy Symptom Assessment; SD = standard deviation; TSS = total symptom scale