Table 2 Factor loadings for factor analysis with oblique rotation

I-1

Do your toes begin to hurt when the ambient temperature or your body temperature rises?

I-6

Are you unable to perform your daily activities due to pain?

I-4

Do you feel pain in your knees when the ambient temperature or your body temperature rises?

I-7

Do your hands begin to hurt on cold days?

I-13

Do you experience any pain when your body temperature rises in the bath?

I-12

Are you immobile on hot days?

I-22

Do you have diarrhea?

I-9

Do your hands begin to hurt while using tap water?

I-24

Do you experience abdominal pain?

I-25

Do you feel nauseous?

V-8

Do you feel bitter because of prejudice toward Fabry disease at your workplace or school?

V-9

Do people at your workplace or school ever make snide remarks about your Fabry disease symptoms?

V-2

Does your Fabry disease treatment impact your work or schooling?

V-4

Do you feel that your hearing difficulty affects work or schooling?

V-3

Do you feel that working outside is difficult?

V-7

Do you get scolded by those around you because you become irritable due to pain from Fabry disease?

IV-5

Do you feel hurt because the people around you do n’t understand you?

IV-6

Do you feel that you can’t properly explain Fabry disease symptoms to the people around you?

III-1

Do you worry about your Fabry disease?

IV-2

Do you feel that playing or doing activities with friends is difficult because of the Fabry disease?

III-4

Do you feel anxious about your future because of the Fabry disease?

VI-6

Do you have trouble socializing with relatives due to the Fabry disease?

I-33

Do you consider yourself mentally weak?

I-31

Do you get dizzy?

I-32

Do you feel you tire easily?

I-21

Do you have trouble socializing due to Fabry disease symptoms?

II-6

Are you concerned about side effects from your current treatment?

I-26

Do you feel that lights are too bright?

I-27

Do you have difficulty seeing at night?

I-29

Do you feel that it is difficult to have conversations because of the ringing in your ears?

I-28

Do you hear ringing in your ears?

I-30

Do you experience sudden, intense ringing in your ears?

I-15

Do you feel pain in your chest or difficulty breathing while walking?

I-14

Do you experience palpitations?

I-17

Do you feel anxious that your heart symptoms will get worse?

I-16

Do you feel pain in your chest or difficulty breathing while climbing stairs?

II-5

Are you anxious about the effectiveness of your current treatment?

I-20

Do you feel anxious that your kidney symptoms will get worse?

I-18

Do your hands swell?