Table 1 High item-item correlation pairs (Pearson’s correlations; N = 83)

I-1: Do your toes begin to hurt when the ambient temperature or your body temperature rises?

I-2: Do your fingers begin to hurt when the ambient temperature or your body temperature rises?

I-3: Do you feel pain in your elbows when the ambient temperature or your body temperature rises?

I-4: Do you feel pain in your knees when the ambient temperature or your body temperature rises?

I-1: Do your toes begin to hurt when the ambient temperature or your body temperature rises?

I-5: Are you unable to exercise due to pain?

I-2: Do your fingers begin to hurt when the ambient temperature or your body temperature rises?

I-6: Are you unable to perform your daily activities due to pain?

I-5: Are you unable to exercise due to pain?

I-6: Are you unable to perform your daily activities due to pain?

I-7: Do your hands begin to hurt on cold days?

I-8: Do your feet begin to hurt on cold days?

I-10: Do you sweat on hot days?

I-11: Do you sweat while exercising?

V-1: Do you feel that the Fabry disease symptoms impact your work or schooling?

V-3: Do you feel that working outside is difficult?

VI-9: Do you feel sorry that your child(ren) is/are suffering from the symptoms of Fabry disease?

VI-10: Do you feel sorry that your child(ren) is/are suffering because they have Fabry disease?