Psychometric evaluation of the Urgency NRS as a new patient-reported outcome measure for patients with ulcerative colitis

Journal of Patient-Reported Outcomes

Table 7 Anchor-based analysis of urgency remission at week 12: PGRS and clinical remission of UC

Urgency NRS score threshold^a	PGRS^b						Clinical remission^c
Urgency NRS score threshold^a	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Youden’s index^d	AUROC^e	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Youden’s index^d	AUROC^e
0	0.26	0.98	0.84	0.74	0.23	0.62	0.20	0.93	0.46	0.80	0.13	0.57
1	0.54	0.92	0.75	0.81	0.46	0.73	0.42	0.82	0.41	0.83	0.25	0.62
2	0.76	0.80	0.64	0.88	0.57	0.78	0.64	0.70	0.38	0.87	0.34	0.67
3	0.85	0.63	0.52	0.90	0.48	0.74	0.78	0.55	0.34	0.90	0.33	0.67
4	0.93	0.49	0.46	0.94	0.42	0.71	0.88	0.43	0.31	0.92	0.31	0.65
5	0.97	0.36	0.42	0.96	0.33	0.67	0.92	0.31	0.28	0.93	0.23	0.62
6	0.99	0.24	0.38	0.99	0.24	0.62	0.96	0.20	0.26	0.94	0.16	0.58
7	1.00	0.14	0.35	0.99	0.14	0.57	0.99	0.12	0.25	0.97	0.11	0.56
8	1.00	0.07	0.33	1.00	0.07	0.53	1.00	0.06	0.24	0.98	0.05	0.53
9	1.00	0.02	0.33	1.00	0.02	0.51	1.00	0.02	0.23	1.00	0.02	0.51
10	1.00	0.00	0.32	-	0.00	-	1.00	0.00	0.23	-	0.00	-

AUROC area under the receiver operating characteristic curve, NRS Numeric Rating Scale, PGRS Patient Global Rating of Severity, UC ulcerative colitis
^aA higher Urgency NRS score represents more severe urgency
^bUC symptom remission was defined as a PGRS score of 1 or 2
^cClinical remission of UC was defined as a Mayo stool frequency subscore of 0, or 1 with a ≥ 1-point decrease from baseline; a Mayo rectal bleeding subscore of 0; and a Mayo endoscopic subscore of 0 or 1 (excluding friability)
^dSensitivity + specificity − 1. Bold: highest value of Youden’s index. A higher value of Youden’s index indicates a better balance of sensitivity and specificity of the potential NRS score threshold in identifying participants with UC remission based on the anchor (PGRS or clinical remission)
^eAUROC was calculated from a logistic regression model with the anchor variable as the dependent variable and urgency remission status (as defined by the Urgency NRS threshold) as the independent variable. Bold: highest value of AUROC