Psychometric evaluation of the Urgency NRS as a new patient-reported outcome measure for patients with ulcerative colitis

Journal of Patient-Reported Outcomes

Table 6 Anchor-based analysis of meaningful change from baseline to week 12: PGRS and PGRC

Urgency NRS score change threshold^a	PGRS^b						PGRC^c
Urgency NRS score change threshold^a	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Youden’s index^d	AUROC^e	Sensitivity	Specificity	Positive predictive value	Negative predictive value	Youden’s index^d	AURC ^e
+ 10	1.00	0.00	0.35	-	0.00	-	1.00	0.00	0.58	-	0.00	-
+ 9	1.00	0.00	0.35	-	0.00	-	1.00	0.00	0.58	-	0.00	-
+ 8	1.00	0.00	0.35	-	0.00	-	1.00	0.00	0.58	-	0.00	-
+ 7	1.00	0.00	0.35	-	0.00	-	1.00	0.00	0.58	-	0.00	-
+ 6	1.00	0.00	0.35	1.00	0.00	0.50	1.00	0.00	0.58	1.00	0.00	0.50
+ 5	1.00	0.01	0.35	1.00	0.01	0.50	1.00	0.01	0.58	0.75	0.01	0.50 ara>
+ 4	1.00	0.01	0.35	1.00	0.01	0.50	1.00	0.01	0.58	0.67	0.01	0.50
+ 3	1.00	0.01	0.35	1.00	0.01	0.51	1.00	0.01	0.58	0.71	0.01	0.50
+ 2	1.00	0.03	0.35	1.00	0.03	0.51	1.00	0.03	0.58	0.83	0.03	0.51
+ 1	1.00	0.06	0.36	0.95	0.05	0.53	0.99	0.07	0.59	0.81	0.06	0.53
0	0.99	0.14	0.38	0.96	0.13	0.57	0.96	0.18	0.62	0.76	0.14	0.57
− 1	0.97	0.35	0.44	0.95	0.32	0.66	0.89	0.42	0.68	0.74	0.31	0.65
− 2	0.90	0.54	0.51	0.91	0.44	0.72	0.77	0.59	0.72	0.65	0.36	0.68
− 3	0.79	0.74	0.61	0.87	0.52	0.76	0.60	0.77	0.78	0.59	0.37	0.69
− 4	0.65	0.85	0.70	0.82	0.50	0.75	0.45	0.86	0.81	0.53	0.31	0.66
− 5	0.48	0.94	0.80	0.77	0.42	0.71	0.31	0.93	0.86	0.50	0.24	0.62
− 6	0.39	0.96	0.82	0.73	0.30	0.65	0.21	0.95	0.85	0.47	0.16	0.58
− 7	0.17	0.99	0.88	0.69	0.16	0.58	0.11	0.98	0.89	0.45	0.09	0.54
− 8	0.06	1.00	0.88	0.67	0.05	0.53	0.04	1.00	0.92	0.43	0.03	0.52
− 9	0.02	1.00	1.00	0.66	0.02	0.51	0.01	1.00	1.00	0.43	0.01	0.51
− 10	0.01	1.00	1.00	0.66	0.01	0.50	0.00	1.00	1.00	0.42	0.00	0.50

AUROC area under the receiver operating characteristic curve, NRS Numeric Rating Scale, PGRC Patient Global Rating of Change, PGRS Patient Global Rating of Severity
^aAn increase in Urgency NRS score represents deterioration and a decrease represents improvement
^bPGRS responders were participants with a ≥ 2-point improvement in PGRS score between baseline and week 12
^cPGRC responders were participants with a PGRC score of 1 or 2 at week 12
^dSensitivity + specificity − 1. Bold: highest value of Youden’s index. A higher value of Youden’s index indicates a better balance of sensitivity and specificity of the potential NRS score change threshold in identifying responders based on the anchor (PGRS or PGRC)
^eAUROC was calculated from a logistic regression model with the anchor variable as the dependent variable and urgency improvement status (as defined by the Urgency NRS threshold) as the independent variable. Bold: highest value of AUROC