| Urgency NRS score | ||||||
---|---|---|---|---|---|---|---|
n | Mean (SD) | Median (range) | LS mean (SE)a | LS mean difference (95% CI)a | p valuea | Cohen’s db | |
Baseline | |||||||
Median PGRS score at baseline | |||||||
  ≤ median (4)c | 713 | 5.4 (2.05) | 5 (0–10) | 5.4 (0.07) | – | – | – |
  > median (4)c | 435 | 7.5 (1.71) | 8 (0–10) | 7.5 (0.09) | 2.1 (1.8, 2.3) |  < 0.0001 | 1.07 |
Week 12 | |||||||
PGRS score at week 12 | |||||||
  ≤ 3 | 638 | 2.5 (1.98) | 2 (0–10) | 2.6 (0.08) | – | – | – |
  > 3 | 448 | 5.4 (2.32) | 4 (0–10) | 5.3 (0.09) | 2.7 (2.4, 2.9) |  < 0.0001 | 1.39 |
Clinical remission at week 12d | |||||||
 Yes | 246 | 2.2 (1.92) | 2 (0–9) | 2.3 (0.14) | – | – | – |
 No | 833 | 4.1 (2.59) | 4 (0–10) | 4.1 (0.08) | 1.8 (1.5, 2.2) |  < 0.0001 | 0.79 |
Clinical response at week 12 | |||||||
 Yes | 670 | 2.8 (2.24) | 2 (0–10) | 2.8 (0.08) | – | – | – |
 No | 409 | 5.1 (2.46) | 5 (0–10) | 5.2 (0.10) | 2.3 (2.1, 2.6) |  < 0.0001 | 1.00 |