Characteristics of health-related quality of life and related factors in patients with brain tumors treated with rehabilitation therapy

Watanabe, Takahiro; Noto, Shinichi; Natsumeda, Manabu; Kimura, Shinji; Tabata, Satoshi; Ikarashi, Fumie; Takano, Mayuko; Tsukamoto, Yoshihiro; Oishi, Makoto

doi:10.1186/s41687-022-00499-y

Journal of Patient-Reported Outcomes

Table 3 Comparison of FIM, KPS, and HRQOL by recurrence and newly diagnosed groups

From: Characteristics of health-related quality of life and related factors in patients with brain tumors treated with rehabilitation therapy

	Recurrence	Newly diagnosed	p value	ES (d)
	n = 20	n = 56
	Mean ± SD	Mean ± SD
FIM	109.8 ± 14.9	117.3 ± 10.6	0.048	0.63
KPS	78.5 ± 15.3	89.1 ± 11.6	0.009	0.84
EQ-5D-5L index score	0.577 ± 0.243	0.729 ± 0.175	0.016	0.78
QLQ-C30 functional domains^a
Physical functioning	50.7 ± 29.5	73.6 ± 24.6	0.004	0.88
Role functioning	43.3 ± 29.3	61.0 ± 33.2	0.032	0.55
Cognitive functioning	58.3 ± 25.6	71.4 ± 24.4	0.056	0.53
Emotional functioning	72.1 ± 20.1	80.7 ± 14.0	0.09	0.54
Social functioning	64.2 ± 31.2	67.9 ± 28.9	0.647	0.13
Global health status	48.3 ± 21.7	53.7 ± 24.6	0.364	0.23
QLQ-C30 symptom domains^a
Nausea and vomiting	12.5 ± 22.9	3.3 ± 9.2	0.094	0.66
Fatigue	52.2 ± 18.1	36.1 ± 20.7	0.002	0.8
Dyspnea	28.3 ± 34.7	15.5 ± 24.6	0.139	0.47
Pain	24.2 ± 19.8	19.9 ± 21.9	0.432	0.2
Insomnia	36.7 ± 37.3	27.4 ± 25.5	0.312	0.32
Appetite loss	23.3 ± 24.4	20.2 ± 27.5	0.641	0.12
Constipation	33.3 ± 32.4	26.8 ± 28.0	0.429	0.22
Diarrhea	5.0 ± 12.2	11.9 ± 17.3	0.06	0.43
Financial difficulties	38.3 ± 34.7	31.5 ± 30.1	0.443	0.22
BN20 symptom domains^b
Future uncertainty	45.4 ± 26.8	30.4 ± 22.2	0.032	0.64
Visual disorder	16.1 ± 23.5	18.1 ± 30.0	0.77	0.07
Motor dysfunction	30.6 ± 27.4	20.8 ± 22.6	0.166	0.41
Communication deficit	25.6 ± 25.5	15.1 ± 20.8	0.11	0.47
Headache	18.3 ± 22.9	24.4 ± 24.2	0.323	0.25
Seizure	5.0 ± 12.2	0.0 ± 0.0	0.083	0.81
Drowsiness	46.7 ± 31.3	29.2 ± 26.3	0.033	0.63
Hair loss	23.3 ± 37.6	25.6 ± 28.4	0.808	0.07
Itchy skin	16.7 ± 20.2	18.5 ± 19.0	0.733	0.09
Weakness of legs	41.7 ± 30.4	40.5 ± 30.3	0.881	0.04
Loss of bladder control	23.3 ± 30.8	11.3 ± 20.4	0.117	0.51

FIM Functional independence measure, KPS Karnofsky performance status, SD Standard deviation, ES Effect size
^aIn EORTC QLQ-C30, functional domains—higher scores are better; symptom domains—lower scores are better
^bIn EORTC BN20 symptom domains, lower scores are better
p value < 0.05 were written in boldface

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