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Table 3 Diagnostic accuracy of legacy measures at established cut-points compared with diagnosis of Any Anxiety Disorder using the Structured Clinical Interview for DSM disorders (SCID)

From: Convergent and criterion validity of PROMIS anxiety measures relative to six legacy measures and a structured diagnostic interview for anxiety in cancer patients

Measure Sensitivity (95% CI) Specificity (95% CI) PPV* (95% CI) NPV** (95% CI)
Mild cut-points         
PROMIS-A-CAT 55 .59 (.43–.76) .79 (.70–.86) .53 (.41–.65) .83 .78–.89
PROMIS-A-SF 55 .67 (.50–.81) .79 (.71–.87) .56 (.44–.68) .86 .80–.92
HADS-A possible .62 (.47–.78) .80 (.72–.88) .55 (.40–.70) .84 .77–.92
DASS-A mild .39 (.23–.55) .78 (.69–.86) .40 (.24–.56) .77 .68–.85
DASS-S mild .27 (.13–41) .94 (.88–.99) .63 (.39–.86) .76 .68–.84
GAD-7 mild .68 (.54–.83) .75 (.67–.84) .52 (.38–.66) .85 .78–.93
DT .46 (.30–.62) .78 (.70–.86) .45 (.29–.61) .79 .70–.87
PSYCH-6 .57 (.41–.73) .85 (.78–.92) .59 (.42–.75) .84 .77–.92
Moderate cut-points         
PROMIS-A-CAT 65 .19 (.08–.32) .97 (.93–1.00) .71 (.43–1.00) .75 .73–.79
PROMIS-A-SF 55 .19 (.08–.33) .97 (.93–1.00) .71 (.44–1.00) .75 .73–.79
HADS-A probable .27 (.13–.41) .94 (.89–.99) .63 (.39–.86) .77 .69–.84
DASS-A moderate .33 (.18–.49) .86 (.79–.93) .48 (.28–.68) .77 .69–.85
DASS-S moderate .16 (.04–.28) .95 (.90–.99) .55 (.25–.84) .74 .66–.82
GAD-7 moderate .24 (.11–.38) .95 (.90–.99) .64 (.39–.89) .76 .68–.83
Optimal Cut-point***         
PROMIS-A-CAT 53 .81 (.68–.92) .72 (.63–.81) .54 (.45–.63) .91 .84–.96
PROMIS-A-SF 53 .78 (.64–.92) .70 (.61–.78) .50 (.42–.60) .89 .83–.95
  1. *PPV Positive Predictive Value; **NPV Negative Predictive Value
  2. *** Selected by maximising Youden’s index