Agreement between older adult patient and caregiver proxy symptom reports

Kroenke, Kurt; Stump, Timothy E.; Monahan, Patrick O.

doi:10.1186/s41687-022-00457-8

Journal of Patient-Reported Outcomes

Table 4 Patient-Caregiver Concordance for Pain, Anxiety, and Depression Scales

From: Agreement between older adult patient and caregiver proxy symptom reports

Item #^a	Item	Item mean (SD)		Spearman correlation^b	Weighted Kappa^c
Item #^a	Item	Patients	Care-givers	Spearman correlation^b	Quadratic	Linear
	PEG pain
1	Pain on average in the past week	4.7 (3.1)	4.8 (3.1)	0.57	0.57	0.43
2	Pain interference with enjoyment of life	3.8 (3.5)	4.1 (3.5)	0.50	0.50	0.37
3	Pain interference with general activity	3.9 (3.4)	4.1 (3.5)	0.48	0.49	0.37
	PEG scale score^d	4.1 (3.1)	4.3 (3.2)	0.58	0.58 (0.49 to 0.66)
	GAD-7 anxiety
3	Worrying too much about different things	0.7 (1.0)	0.8 (1.0)	0.31	0.30	0.24
2	Not being able to stop or control worrying	0.5 (0.9)	0.7 (1.0)	0.31	0.27	0.22
6	Becoming easily annoyed or irritable	0.5 (0.7)	0.7 (0.9)	0.30	0.25	0.24
4	Trouble relaxing	0.5 (0.9)	0.6 (0.9)	0.30	0.23	0.23
1	Feeling or appearing nervous, anxious or on edge	0.5 (0.8)	0.6 (0.8)	0.27	0.22	0.22
5	Being so restless that it is hard to sit still	0.3 (0.7)	0.3 (0.7)	0.18	0.16	0.16
7	Feeling or appearing afraid as if something awful might happen	0.3 (0.7)	0.3 (0.7)	0.09	0.07	0.08
	GAD-7 scale score^d	3.3 (2.0)	3.9 (4.5)	0.31	0.28 (0.16 to 0.39)
	PHQ-8 depression
5	Feeling tired or having little energy	1.2 (1.1)	1.2 (1.1)	0.33	0.31	0.25
4	Poor appetite or overeating	0.7 (1.0)	0.7 (1.0)	0.34	0.30	0.24
2	Feeling or appearing down, depressed, or hopeless	0.4 (0.8)	0.5 (0.9)	0.31	0.30	0.26
3	Trouble falling asleep, trouble staying asleep, or sleeping too much	0.9 (1.1)	0.9 (1.1)	0.27	0.25	0.21
7	Trouble concentrating on things such as reading the newspaper or watching television	0.4 (0.8)	0.4 (0.8)	0.09	0.15	0.09
6	Indicating that s/he feels bad about self, is a failure, or has let self or family down	0.3 (0.8)	0.4 (0.8)	0.22	0.13	0.14
1	Little interest or little pleasure in doing things	0.6 (0.9)	0.6 (0.9)	0.17	0.11	0.11
8	Moving or speaking so slowly that other people could have noticed. …Or the opposite–being so fidgety or restless that s/he has been moving around a lot more than usual	0.5 (0.9)	0.4 (0.9)	0.08	0.06	0.05
	PHQ-8 scale score^d	5.0 (4.6)	5.2 (5.0)	0.34	0.25 (0.13–0.36)

^aItems for each scale are ordered in table from highest to lowest quadratic weighted kappa
^bMost of the Spearman correlations are highly significant (p < .0001) except for items only significant at p < .05 (PHQ-8 items 1, 6; GAD-7 items 1, 5) or those not significant (PHQ-8 items 7, 8; GAD-7 item 7)
^cAll weighted kappa values are significant (i.e., 95% CI does not include 0) except for GAD-7 items 5 and 7 and PHQ-8 items 1, 6, 7 and 8 (quadratic and linear)
^dFor scale scores, the value under the weighted kappa column is the Intraclass Correlation Coefficient (ICC) with 95% CI, calculated using the absolute agreement version of the ICC and specifying rater (patient vs their caregiver) as a fixed effect

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