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Table 4 The primary outcome measures of the FACT-B and the FACT-Cog in the treatment subgroups

From: Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function

Variable G Mean (SD) n Change
(%)
IG T* F–T F–G F–GxT η2
(T)
η2
(GxT)
T0 T1
FACT-B
(0–148)
SC 114.5 ± 13.9 98.8 ± 14.7 22 − 13.2 ± 11.9 a 82.62*** 0.17NS 4.12** 0.52 0.14
SCR 116.7 ± 12.1 94.8 ± 18.9 17 − 18.6 ± 13.8 a      
SR 113.5 ± 16.9 103.8 ± 19.2 27 − 8.8 ± 8.6 a      
S 111.4 ± 9.1 103.5 ± 13.4 13 − 7.3 ± 7.5 a      
PWB
(0–28)
SC 24.7 ± 2.1 19.8 ± 4.9 22 − 19.5 ± 20.5 a 70.47*** 1.35NS 2.26NS 0.48 0.08
SCR 23.9 ± 2.9 16.8 ± 6.3 17 − 29.7 ± 23.4 a      
SR 24.0 ± 3.8 20.0 ± 5.2 27 − 16.7 ± 17.0 a      
S 24.1 ± 2.8 21.3 ± 4.1 13 − 11.5 ± 12.9 a      
SWB
(0–28)
SC 23.0 ± 3.4 20.2 ± 3.4 22 − 11.5 ± 14.4 a 36.35*** 0.86NS 2.60NS 0.33 0.09
SCR 24.8 ± 3.0 21.0 ± 3.9 17 − 15.3 ± 10.8 a      
SR 22.4 ± 3.9 21.3 ± 5.0 27 − 4.2 ± 20.1       
S 21.8 ± 3.5 19.9 ± 5.0 13 − 9.1 ± 17.2       
EWB
(0–24)
SC 15.2 ± 4.8 15.7 ± 3.9 22 + 7.7 ± 29.9   0.47NS 0.09NS 0.16NS 0 0
SCR 15.8 ± 3.1 15.7 ± 3.5 17 + 0.7 ± 20.1       
SR 15.1 ± 4.6 15.5 ± 4.9 27 + 3.4 ± 22.2       
S 15.9 ± 2.9 16.0 ± 2.5 13 + 1.3 ± 8.2       
FWB
(0–28)
SC 19.4 ± 6.5 15.7 ± 5.4 22 − 16.7 ± 15.5 a 51.36*** 0.33NS 3.25* 0.41 0.12
SCR 20.9 ± 5.2 16.1 ± 4.3 17 − 19.8 ± 20.5 a      
SR 20.0 ± 4.7 17.7 ± 4.4 27 − 10.3 ± 11.9 a      
S 18.8 ± 3.8 17.5 ± 3.3 13 − 5.4 ± 12.5       
BCS
(0–40)
SC 32.0 ± 3.5 27.5 ± 4.8 22 − 14.1 ± 12.3 a 76.11*** 1.03NS 3.98* 0.5 0.13
SCR 31.4 ± 4.4 25.2 ± 6.3 17 − 19.7 ± 14.8 a      
SR 32.0 ± 4.1 29.3 ± 5.5 27 − 9.1 ± 10.7 a      
S 30.8 ± 4.1 28.7 ± 5.0 13 − 6.8 ± 10.6 a      
FACT- SC 118.1 ± 13.4 100.4 ± 11.8 22 − 14.9 ± 6.0 a 168.53*** 1.64NS 27.93*** 0.69 0.53
Cog
(0–132)
SCR 117.9 ± 11.8 93.6 ± 13.8 17 − 20.5 ± 9.4 a      
SR 116.3 ± 14.5 110.9 ± 18.4 27 − 5.1 ± 6.6 a      
S 116.9 ± 18.6 114.5 ± 14.9 13 − 1.3 ± 6.5       
PCI
(0–72)
SC 64.2 ± 10.0 56.7 ± 9.1 22 − 11.6 ± 5.0 a 118.70*** 1.09NS 15.07*** 0.61 0.38
SCR 64.8 ± 7.4 52.9 ± 9.2 17 − 18.1 ± 11.6 a      
SR 64.5 ± 7.7 61.1 ± 9.8 27 − 5.6 ± 7.1 a      
S 64.5 ± 10.0 62.8 ± 8.3 13 − 2.2 ± 7.1       
OTH
(0–16)
SC 15.5 ± 1.0 13.7 ± 2.0 22 − 11.9 ± 11.7 a 55.83*** 1.14NS 10.82*** 0.43 0.3
SCR 15.4 ± 1.5 13.1 ± 1.7 17 − 15.0 ± 9.5 a      
SR 15.6 ± 0.8 15.2 ± 0.9 27 − 2.0 ± 5.7       
S 15.7 ± 0.6 15.4 ± 1.0 13 − 1.9 ± 5.1       
PCA
(0–28)
SC 25.1 ± 3.2 20.6 ± 3.2 22 − 17.2 ± 11.4 a 91.45*** 0.76NS 17.40*** 0.55 0.41
SCR 24.1 ± 3.2 19.6 ± 3.0 17 − 18.4 ± 7.8 a      
SR 23.4 ± 4.8 22.6 ± 5.1 27 − 3.6 ± 8.3 a      
S 24.2 ± 4.5 23.7 ± 4.0 13 − 1.7 ± 6.7       
QoL
(0–16)
SC 13.3 ± 2.8 9.3 ± 1.9 22 − 28.2 ± 14.0 a 85.35*** 1.44NS 22.49*** 0.53 0.47
SCR 13.6 ± 2.6 8.0 ± 1.9 17 − 39.2 ± 17.1 a      
SR 12.8 ± 3.4 11.9 ± 4.2 27 − 8.2 ± 20.1       
S 12.5 ± 4.6 12.7 ± 3.0 13 + 1.8 ± 14.6       
  1. Data are expressed as means ± standard deviation (SD); Change in percent (%) represent the average score change of each patient
  2. For FACT-B and FACT-Cog, higher scores indicate a subjectively better HRQoL or PCF
  3. SC, Surgery + Chemotherapy; SCR, Surgery + Chemotherapy + Radiation Therapy; SR, Surgery + Radiation Therapy; S, Surgery; n, number of patients; NS, not significant; T, time; G, group; F–T, main effect for time group; F–G, main effect for group regardless of the time; GxT, interaction between time and group; IG T, individual group for time
  4. *p < 0.05; **p < 0.01; ***p < 0.001
  5. "a" expresses statistically significant effects (p < 0.05) from basline to T1 of each group of the variable