Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function

Grusdat, Niklas Paul; Stäuber, Alexander; Tolkmitt, Marion; Schnabel, Jens; Schubotz, Birgit; Wright, Peter Richard; Heydenreich, Marc; Zermann, Dirk-Henrik; Schulz, Henry

doi:10.1186/s41687-022-00422-5

Journal of Patient-Reported Outcomes

Table 4 The primary outcome measures of the FACT-B and the FACT-Cog in the treatment subgroups

From: Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function

Variable	G	Mean (SD)		n	Change (%)	IG T*	F–T	F–G	F–GxT	η² (T)	η² (GxT)
Variable	G	T0	T1	n	Change (%)	IG T*	F–T	F–G	F–GxT	η² (T)	η² (GxT)
FACT-B (0–148)	SC	114.5 ± 13.9	98.8 ± 14.7	22	− 13.2 ± 11.9	a	82.62***	0.17^NS	4.12**	0.52	0.14
	SCR	116.7 ± 12.1	94.8 ± 18.9	17	− 18.6 ± 13.8	a
	SR	113.5 ± 16.9	103.8 ± 19.2	27	− 8.8 ± 8.6	a
	S	111.4 ± 9.1	103.5 ± 13.4	13	− 7.3 ± 7.5	a
PWB (0–28)	SC	24.7 ± 2.1	19.8 ± 4.9	22	− 19.5 ± 20.5	a	70.47***	1.35^NS	2.26^NS	0.48	0.08
	SCR	23.9 ± 2.9	16.8 ± 6.3	17	− 29.7 ± 23.4	a
	SR	24.0 ± 3.8	20.0 ± 5.2	27	− 16.7 ± 17.0	a
	S	24.1 ± 2.8	21.3 ± 4.1	13	− 11.5 ± 12.9	a
SWB (0–28)	SC	23.0 ± 3.4	20.2 ± 3.4	22	− 11.5 ± 14.4	a	36.35***	0.86^NS	2.60^NS	0.33	0.09
	SCR	24.8 ± 3.0	21.0 ± 3.9	17	− 15.3 ± 10.8	a
	SR	22.4 ± 3.9	21.3 ± 5.0	27	− 4.2 ± 20.1
	S	21.8 ± 3.5	19.9 ± 5.0	13	− 9.1 ± 17.2
EWB (0–24)	SC	15.2 ± 4.8	15.7 ± 3.9	22	+ 7.7 ± 29.9		0.47^NS	0.09^NS	0.16^NS	0	0
	SCR	15.8 ± 3.1	15.7 ± 3.5	17	+ 0.7 ± 20.1
	SR	15.1 ± 4.6	15.5 ± 4.9	27	+ 3.4 ± 22.2
	S	15.9 ± 2.9	16.0 ± 2.5	13	+ 1.3 ± 8.2
FWB (0–28)	SC	19.4 ± 6.5	15.7 ± 5.4	22	− 16.7 ± 15.5	a	51.36***	0.33^NS	3.25*	0.41	0.12
	SCR	20.9 ± 5.2	16.1 ± 4.3	17	− 19.8 ± 20.5	a
	SR	20.0 ± 4.7	17.7 ± 4.4	27	− 10.3 ± 11.9	a
	S	18.8 ± 3.8	17.5 ± 3.3	13	− 5.4 ± 12.5
BCS (0–40)	SC	32.0 ± 3.5	27.5 ± 4.8	22	− 14.1 ± 12.3	a	76.11***	1.03^NS	3.98*	0.5	0.13
	SCR	31.4 ± 4.4	25.2 ± 6.3	17	− 19.7 ± 14.8	a
	SR	32.0 ± 4.1	29.3 ± 5.5	27	− 9.1 ± 10.7	a
	S	30.8 ± 4.1	28.7 ± 5.0	13	− 6.8 ± 10.6	a
FACT-	SC	118.1 ± 13.4	100.4 ± 11.8	22	− 14.9 ± 6.0	a	168.53***	1.64^NS	27.93***	0.69	0.53
Cog (0–132)	SCR	117.9 ± 11.8	93.6 ± 13.8	17	− 20.5 ± 9.4	a
	SR	116.3 ± 14.5	110.9 ± 18.4	27	− 5.1 ± 6.6	a
	S	116.9 ± 18.6	114.5 ± 14.9	13	− 1.3 ± 6.5
PCI (0–72)	SC	64.2 ± 10.0	56.7 ± 9.1	22	− 11.6 ± 5.0	a	118.70***	1.09^NS	15.07***	0.61	0.38
	SCR	64.8 ± 7.4	52.9 ± 9.2	17	− 18.1 ± 11.6	a
	SR	64.5 ± 7.7	61.1 ± 9.8	27	− 5.6 ± 7.1	a
	S	64.5 ± 10.0	62.8 ± 8.3	13	− 2.2 ± 7.1
OTH (0–16)	SC	15.5 ± 1.0	13.7 ± 2.0	22	− 11.9 ± 11.7	a	55.83***	1.14^NS	10.82***	0.43	0.3
	SCR	15.4 ± 1.5	13.1 ± 1.7	17	− 15.0 ± 9.5	a
	SR	15.6 ± 0.8	15.2 ± 0.9	27	− 2.0 ± 5.7
	S	15.7 ± 0.6	15.4 ± 1.0	13	− 1.9 ± 5.1
PCA (0–28)	SC	25.1 ± 3.2	20.6 ± 3.2	22	− 17.2 ± 11.4	a	91.45***	0.76^NS	17.40***	0.55	0.41
	SCR	24.1 ± 3.2	19.6 ± 3.0	17	− 18.4 ± 7.8	a
	SR	23.4 ± 4.8	22.6 ± 5.1	27	− 3.6 ± 8.3	a
	S	24.2 ± 4.5	23.7 ± 4.0	13	− 1.7 ± 6.7
QoL (0–16)	SC	13.3 ± 2.8	9.3 ± 1.9	22	− 28.2 ± 14.0	a	85.35***	1.44^NS	22.49***	0.53	0.47
	SCR	13.6 ± 2.6	8.0 ± 1.9	17	− 39.2 ± 17.1	a
	SR	12.8 ± 3.4	11.9 ± 4.2	27	− 8.2 ± 20.1
	S	12.5 ± 4.6	12.7 ± 3.0	13	+ 1.8 ± 14.6

Data are expressed as means ± standard deviation (SD); Change in percent (%) represent the average score change of each patient
For FACT-B and FACT-Cog, higher scores indicate a subjectively better HRQoL or PCF
SC, Surgery + Chemotherapy; SCR, Surgery + Chemotherapy + Radiation Therapy; SR, Surgery + Radiation Therapy; S, Surgery; n, number of patients; NS, not significant; T, time; G, group; F–T, main effect for time group; F–G, main effect for group regardless of the time; GxT, interaction between time and group; IG T, individual group for time
*p < 0.05; **p < 0.01; ***p < 0.001
"a" expresses statistically significant effects (p < 0.05) from basline to T1 of each group of the variable

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