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Journal of Patient-Reported Outcomes

Table 5 Meaningful change thresholds for WI-NRS (phase 3 cohort)

From: Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus

Criteria

N

Mean WI-NRS change scorea (SD)

Mean % change from baseline

Effect size (Cohen’s d)

Primary anchor-based approach

 PGI-C minimally improved

198

− 1.85 (1.73)

− 25.73

1.09

Secondary anchor-based approach

 PGI-C much improved

209

− 3.54 (2.08)

− 51.02

2.04

 PGI-C minimally or much improved

407

− 2.72 (2.09)

− 38.72

1.48

  1. PGI-C, Patient global impression of change; SD, standard deviation; WI-NRS, Worst Itching Intensity Numerical Rating Scale
  2. aChange from baseline to end of treatment
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