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Table 3 Concept saturation analysis

From: A novel patient-reported outcome instrument assessing the symptoms of paroxysmal nocturnal hemoglobinuria, the PNH-SQ

Symptom

Set 1 n = 5

Set 2 n = 5

Set 3 n = 5

Saturation met?

Fatigue

Y

Sleep problems

Y

Abdominal pain

Y

Chest discomfort

Y

Shortness of breath

Y

Muscle weakness

*

Y

Cognitive difficulties

Y

Difficulties swallowing

Y

Sexual difficulties

*

Y

Yellow eyes

Y

Headache

Y

Sore spleen

Y

Sensitive nerves

Y

Back pain

Y

Dark urine

Y

Paleness

Y

Bruising

Y

Heartburn

Y

Hoarse voice

*

Y

Fast heart rate

*

Y

Muscle aches

*

Y

Urinary spasms

Y

Ascites

*

N

  1. Concept discussed in interview set
  2. ✖ Concept not discussed in interview set
  3. N No, Y Yes
  4. *Represents emergence of a new concept