Table 4 Differences in HRQOL scores and margins of small effect size by mode of administration
Domain questionnaire and scale | PSAQ-CSAQ mean diff (95% CI) | Margin of small effect size | CSAQ-IVR mean diff (95% CI) | Margin of small effect size | IVR-PSAQ Mean diff (95% CI) | Margin of small effect size |
|---|---|---|---|---|---|---|
Global/general health | ||||||
PROMIS global mental | − 1.05 (− 2.01, − 0.09) | ± 1.67 | − 0.77 (− 1.71, 0.17) | ± 1.64 | 1.82 (0.89, 2.75) | ± 1.62 |
PROMIS global physical | − 0.41 (− 1.39, 0.57) | ± 1.70 | − 0.03 (− 1.00, 0.94) | ± 1.69 | 0.44 (− 0.52, 1.41) | ± 1.67 |
NRS overall QOL | − 1.76 (− 4.10, 0.58) | ± 4.09 | 2.19 (− 0.20, 4.58) | ± 4.17 | − 0.43 (− 2.85, 1.99) | ± 4.22 |
NRS emotional well-being | − 1.44 (− 3.75, 0.88) | ± 4.05 | 1.82 (− 0.46, 4.10) | ± 3.99 | − 0.38 (− 2.76, 1.99) | ± 4.15 |
NRS mental well-being | − 0.88 (− 3.06, 1.29) | ± 3.80 | 2.24 (0.06, 4.42) | ± 3.81 | − 1.36 (− 3.61, 0.89) | ± 3.92 |
Physical function | ||||||
PROMIS physical function | − 0.39 (− 1.35, 0.58) | ± 1.68 | − 0.05 (− 0.98, 0.88) | ± 1.61 | 0.43 (− 0.48, 1.35) | ± 1.60 |
NRS Physical well-being | − 1.55 (− 3.99, 0.90) | ± 4.26 | − 0.72 (− 3.15, 1.70) | ± 4.18 | 2.27 (− 0.27, 4.82) | ± 4.41 |
Social function | ||||||
PROMIS social function | − 0.51 (− 1.61, 0.59) | ± 1.92 | − 0.22 (− 1.28, 0.84) | ± 1.84 | 0.73 (− 0.34, 1.79) | ± 1.85 |
NRS social activity | − 2.43 (− 5.32, 0.46) | ± 5.01 | − 1.16 (− 3.95, 1.62) | ± 4.80 | 3.59 (0.70, 6.48) | ± 4.99 |
Emotional distress—anxiety | ||||||
PROMIS anxiety | 0.77 (− 0.35, 1.88) | ± 1.94 | 0.21 (− 0.88, 1.30) | ± 1.89 | − 0.98 (− 2.08, 0.12) | ± 1.90 |
NRS anxiety | 0.60 (− 2.51, 3.70) | ± 5.40 | 5.01 (2.02, 7.99) | ± 5.16 | − 5.60 (− 8.54, − 2.66) | ± 5.08 |
PRO-CTCAE anxiety frequency | 2.89 (− 0.04, 5.83) | ± 5.10 | 4.36 (1.48, 7.23) | ± 4.97 | − 7.25 (− 10.2, − 4.33) | ± 5.05 |
PRO-CTCAE anxiety severity | 2.66 (− 0.05, 5.37) | ± 4.72 | 3.09 (0.47, 5.72) | ± 4.53 | − 5.76 (− 8.44, − 3.07) | ± 4.64 |
PRO-CTCAE anxiety interference | 1.62 (− 1.03, 4.27) | ± 4.62 | 3.10 (0.62, 5.58) | ± 4.28 | − 4.72 (− 7.22, − 2.22) | ± 4.32 |
Emotional distress—depression | ||||||
PROMIS depression | 0.57 (− 0.47, 1.60) | ± 1.80 | − 0.56 (− 1.53, 0.41) | ± 1.68 | − 0.01 (− 0.99, 0.97) | ± 1.70 |
NRS depression | 0.75 (− 1.92, 3.42) | ± 4.63 | 3.95 (1.52, 6.39) | ± 4.21 | − 4.70 (− 7.14, − 2.27) | ± 4.21 |
PRO-CTCAE cheer Frequency | 0.62 (− 1.99, 3.23) | ± 4.53 | 3.05 (0.59, 5.51) | ± 4.25 | − 3.67 (− 6.11, − 1.23) | ± 4.22 |
PRO-CTCAE cheer severity | 1.31 (− 1.17, 3.78) | ± 4.29 | 2.66 (0.43, 4.89) | ± 3.84 | − 3.97 (− 6.27, − 1.66) | ± 3.97 |
PRO-CTCAE cheer interference | 1.73 (− 0.64, 4.09) | ± 4.11 | 1.72 (− 0.44, 3.89) | ± 3.73 | − 3.45 (− 5.67, − 1.23) | ± 3.83 |
PRO-CTCAE sad frequency | 1.66 (− 1.10, 4.41) | ± 4.78 | 3.48 (0.88, 6.07) | ± 4.47 | − 5.13 (− 7.71, − 2.55) | ± 4.44 |
PRO-CTCAE sad severity | 0.78 (− 1.75, 3.30) | ± 4.38 | 3.35 (0.91, 5.78) | ± 4.20 | − 4.12 (− 6.53, − 1.72) | ± 4.15 |
PRO-CTCAE sad interference | 1.14 (− 1.36, 3.64) | ± 4.34 | 2.30 (− 0.04, 4.64) | ± 4.04 | − 3.44 (− 5.79, − 1.09) | ± 4.05 |
Fatigue | ||||||
PROMIS fatigue | 0.72 (− 0.34, 1.77) | ± 1.84 | 1.31 (0.25, 2.36) | ± 1.82 | − 2.02 (− 3.05, − 1.00) | ± 1.77 |
NRS fatigue | 1.17 (− 1.89, 4.22) | ± 5.32 | 5.69 (2.68, 8.69) | ± 5.19 | − 6.85 (− 9.80, − 3.91) | ± 5.07 |
PRO-CTCAE fatigue severity | 1.38 (− 1.39, 4.15) | ± 4.83 | 3.34 (0.56, 6.12) | ± 4.79 | − 4.72 (− 7.46, − 1.98) | ± 4.72 |
PRO-CTCAE fatigue interference | 0.47 (− 2.66, 3.60) | ± 5.46 | 4.55 (1.50, 7.60) | ± 5.27 | − 5.02 (− 8.02, − 2.02) | ± 5.17 |
Sleep | ||||||
PROMIS sleep disturbance | 0.90 (− 0.19, 1.98) | ± 1.90 | − 0.35 (− 1.40, 0.71) | ± 1.82 | − 0.55 (− 1.62, 0.53) | ± 1.86 |
NRS sleep overall | 2.79 (− 0.00, 5.59) | ± 4.88 | − 0.64 (− 3.36, 2.08) | ± 4.69 | − 2.15 (− 4.97, 0.67) | ± 4.87 |
PRO-CTCAE sleep severity | 3.70 (0.69, 6.72) | ± 5.26 | 2.11 (− 0.88, 5.09) | ± 5.16 | − 5.81 (− 8.86, − 2.76) | ± 5.28 |
PRO-CTCAE sleep interference | 0.39 (− 2.62, 3.39) | ± 5.23 | 4.12 (1.20, 7.04) | ± 5.05 | − 4.50 (− 7.41, − 1.60) | ± 5.02 |
Pain | ||||||
PROMIS pain intensity | 0.16 (− 1.07, 1.40) | ± 2.16 | 1.05 (− 0.20, 2.31) | ± 2.18 | − 1.22 (− 2.45, 0.02) | ± 2.14 |
PROMIS pain interference | 0.56 (− 0.58, 1.70) | ± 1.99 | 0.62 (− 0.51, 1.75) | ± 1.95 | − 1.18 (− 2.30, − 0.06) | ± 1.94 |
NRS pain frequency | 1.53 (− 1.80, 4.85) | ± 5.81 | 1.79 (− 1.53, 5.11) | ± 5.74 | − 3.32 (− 6.68, 0.04) | ± 5.81 |
NRS pain severity | − 0.02 (− 3.07, 3.03) | ± 5.33 | 2.29 (− 0.76, 5.34) | ± 5.26 | − 2.27 (− 5.26, 0.72) | ± 5.17 |
PRO-CTCAE pain frequency | − 0.56 (− 4.15, 3.02) | ± 6.26 | 3.60 (− 0.09, 7.29) | ± 6.37 | − 3.04 (− 6.64, 0.57) | ± 6.24 |
PRO-CTCAE pain severity | − 0.12 (− 3.25, 3.01) | ± 5.47 | 1.96 (− 1.30, 5.22) | ± 5.63 | − 1.83 (− 5.02, 1.36) | ± 5.52 |
PRO-CTCAE pain interference | − 0.17 (− 3.41, 3.08) | ± 5.66 | 2.68 (− 0.54, 5.89) | ± 5.56 | − 2.51 (− 5.67, 0.66) | ± 5.48 |