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Table 4 Differences in HRQOL scores and margins of small effect size by mode of administration

From: Score equivalence of paper-, tablet-, and interactive voice response system-based versions of PROMIS, PRO-CTCAE, and numerical rating scales among cancer patients

Domain questionnaire and scale PSAQ-CSAQ mean diff (95% CI) Margin of small effect size CSAQ-IVR mean diff (95% CI) Margin of small effect size IVR-PSAQ Mean diff (95% CI) Margin of small effect size
Global/general health       
PROMIS global mental − 1.05 (− 2.01, − 0.09) ± 1.67 − 0.77 (− 1.71, 0.17) ± 1.64 1.82 (0.89, 2.75) ± 1.62
PROMIS global physical − 0.41 (− 1.39, 0.57) ± 1.70 − 0.03 (− 1.00, 0.94) ± 1.69 0.44 (− 0.52, 1.41) ± 1.67
NRS overall QOL − 1.76 (− 4.10, 0.58) ± 4.09 2.19 (− 0.20, 4.58) ± 4.17 − 0.43 (− 2.85, 1.99) ± 4.22
NRS emotional well-being − 1.44 (− 3.75, 0.88) ± 4.05 1.82 (− 0.46, 4.10) ± 3.99 − 0.38 (− 2.76, 1.99) ± 4.15
NRS mental well-being − 0.88 (− 3.06, 1.29) ± 3.80 2.24 (0.06, 4.42) ± 3.81 − 1.36 (− 3.61, 0.89) ± 3.92
Physical function       
PROMIS physical function − 0.39 (− 1.35, 0.58) ± 1.68 − 0.05 (− 0.98, 0.88) ± 1.61 0.43 (− 0.48, 1.35) ± 1.60
NRS Physical well-being − 1.55 (− 3.99, 0.90) ± 4.26 − 0.72 (− 3.15, 1.70) ± 4.18 2.27 (− 0.27, 4.82) ± 4.41
Social function       
PROMIS social function − 0.51 (− 1.61, 0.59) ± 1.92 − 0.22 (− 1.28, 0.84) ± 1.84 0.73 (− 0.34, 1.79) ± 1.85
NRS social activity − 2.43 (− 5.32, 0.46) ± 5.01 − 1.16 (− 3.95, 1.62) ± 4.80 3.59 (0.70, 6.48) ± 4.99
Emotional distress—anxiety       
PROMIS anxiety 0.77 (− 0.35, 1.88) ± 1.94 0.21 (− 0.88, 1.30) ± 1.89 − 0.98 (− 2.08, 0.12) ± 1.90
NRS anxiety 0.60 (− 2.51, 3.70) ± 5.40 5.01 (2.02, 7.99) ± 5.16 − 5.60 (− 8.54, − 2.66) ± 5.08
PRO-CTCAE anxiety frequency 2.89 (− 0.04, 5.83) ± 5.10 4.36 (1.48, 7.23) ± 4.97 − 7.25 (− 10.2, − 4.33) ± 5.05
PRO-CTCAE anxiety severity 2.66 (− 0.05, 5.37) ± 4.72 3.09 (0.47, 5.72) ± 4.53 − 5.76 (− 8.44, − 3.07) ± 4.64
PRO-CTCAE anxiety interference 1.62 (− 1.03, 4.27) ± 4.62 3.10 (0.62, 5.58) ± 4.28 − 4.72 (− 7.22, − 2.22) ± 4.32
Emotional distress—depression       
PROMIS depression 0.57 (− 0.47, 1.60) ± 1.80 − 0.56 (− 1.53, 0.41) ± 1.68 − 0.01 (− 0.99, 0.97) ± 1.70
NRS depression 0.75 (− 1.92, 3.42) ± 4.63 3.95 (1.52, 6.39) ± 4.21 − 4.70 (− 7.14, − 2.27) ± 4.21
PRO-CTCAE cheer Frequency 0.62 (− 1.99, 3.23) ± 4.53 3.05 (0.59, 5.51) ± 4.25 − 3.67 (− 6.11, − 1.23) ± 4.22
PRO-CTCAE cheer severity 1.31 (− 1.17, 3.78) ± 4.29 2.66 (0.43, 4.89) ± 3.84 − 3.97 (− 6.27, − 1.66) ± 3.97
PRO-CTCAE cheer interference 1.73 (− 0.64, 4.09) ± 4.11 1.72 (− 0.44, 3.89) ± 3.73 − 3.45 (− 5.67, − 1.23) ± 3.83
PRO-CTCAE sad frequency 1.66 (− 1.10, 4.41) ± 4.78 3.48 (0.88, 6.07) ± 4.47 − 5.13 (− 7.71, − 2.55) ± 4.44
PRO-CTCAE sad severity 0.78 (− 1.75, 3.30) ± 4.38 3.35 (0.91, 5.78) ± 4.20 − 4.12 (− 6.53, − 1.72) ± 4.15
PRO-CTCAE sad interference 1.14 (− 1.36, 3.64) ± 4.34 2.30 (− 0.04, 4.64) ± 4.04 − 3.44 (− 5.79, − 1.09) ± 4.05
Fatigue       
PROMIS fatigue 0.72 (− 0.34, 1.77) ± 1.84 1.31 (0.25, 2.36) ± 1.82 − 2.02 (− 3.05, − 1.00) ± 1.77
NRS fatigue 1.17 (− 1.89, 4.22) ± 5.32 5.69 (2.68, 8.69) ± 5.19 − 6.85 (− 9.80, − 3.91) ± 5.07
PRO-CTCAE fatigue severity 1.38 (− 1.39, 4.15) ± 4.83 3.34 (0.56, 6.12) ± 4.79 − 4.72 (− 7.46, − 1.98) ± 4.72
PRO-CTCAE fatigue interference 0.47 (− 2.66, 3.60) ± 5.46 4.55 (1.50, 7.60) ± 5.27 − 5.02 (− 8.02, − 2.02) ± 5.17
Sleep       
PROMIS sleep disturbance 0.90 (− 0.19, 1.98) ± 1.90 − 0.35 (− 1.40, 0.71) ± 1.82 − 0.55 (− 1.62, 0.53) ± 1.86
NRS sleep overall 2.79 (− 0.00, 5.59) ± 4.88 − 0.64 (− 3.36, 2.08) ± 4.69 − 2.15 (− 4.97, 0.67) ± 4.87
PRO-CTCAE sleep severity 3.70 (0.69, 6.72) ± 5.26 2.11 (− 0.88, 5.09) ± 5.16 − 5.81 (− 8.86, − 2.76) ± 5.28
PRO-CTCAE sleep interference 0.39 (− 2.62, 3.39) ± 5.23 4.12 (1.20, 7.04) ± 5.05 − 4.50 (− 7.41, − 1.60) ± 5.02
Pain       
PROMIS pain intensity 0.16 (− 1.07, 1.40) ± 2.16 1.05 (− 0.20, 2.31) ± 2.18 − 1.22 (− 2.45, 0.02) ± 2.14
PROMIS pain interference 0.56 (− 0.58, 1.70) ± 1.99 0.62 (− 0.51, 1.75) ± 1.95 − 1.18 (− 2.30, − 0.06) ± 1.94
NRS pain frequency 1.53 (− 1.80, 4.85) ± 5.81 1.79 (− 1.53, 5.11) ± 5.74 − 3.32 (− 6.68, 0.04) ± 5.81
NRS pain severity − 0.02 (− 3.07, 3.03) ± 5.33 2.29 (− 0.76, 5.34) ± 5.26 − 2.27 (− 5.26, 0.72) ± 5.17
PRO-CTCAE pain frequency − 0.56 (− 4.15, 3.02) ± 6.26 3.60 (− 0.09, 7.29) ± 6.37 − 3.04 (− 6.64, 0.57) ± 6.24
PRO-CTCAE pain severity − 0.12 (− 3.25, 3.01) ± 5.47 1.96 (− 1.30, 5.22) ± 5.63 − 1.83 (− 5.02, 1.36) ± 5.52
PRO-CTCAE pain interference − 0.17 (− 3.41, 3.08) ± 5.66 2.68 (− 0.54, 5.89) ± 5.56 − 2.51 (− 5.67, 0.66) ± 5.48
  1. Results in bold text indicate where an upper or lower confidence limit exceeds the margin of small effect size. PSAQ means paper-and-pencil self-administered questionnaire, CSAQ computerized self-administered questionnaire, and IVR questionnaire completed using interactive voice recording. The PROMIS scores were on a T-score metric, whereas NRS and PRO-CTCAE items were transformed to 0–100 scale